© 2011

Vaccines against Allergies

  • Rudolf Valenta
  • Robert L. Coffman


  • We are celebrating this year the hundred years´ anniversary of allergen-specific immunotherapy.

  • In 1911 Leonard Noon published his seminal work “Prophylactic inoculation against hay fever” describing his attempts to achieve active immunity against “grass pollen toxin” by administering increasing doses of grass pollen extract before the grass pollen season to allergic patients.

  • Although it was unknown at that time that allergy represents an immunological hypersensitivity disease, the treatment was effective and many observations made by Noon remained valid until today.


Part of the Current Topics in Microbiology and Immunology book series (CT MICROBIOLOGY, volume 352)

Table of contents

  1. Front Matter
    Pages i-xi
  2. Melanie L. Conrad, Harald Renz, Kurt Blaser
    Pages 1-26
  3. Oliver Cromwell, Verena Niederberger, Friedrich Horak, Helmut Fiebig
    Pages 27-42
  4. G. Pauli, Hans-Jørgen Malling
    Pages 43-54
  5. Philip Rancitelli, Alison Hofmann, A. Wesley Burks
    Pages 55-69
  6. Gabriela Senti, Pål Johansen, Thomas M. Kündig
    Pages 71-84
  7. Laurent Mascarell, Aline Zimmer, Laurence Van Overtvelt, Sophie Tourdot, Philippe Moingeon
    Pages 85-105
  8. Mark Larché
    Pages 107-119
  9. Johanna Edlmayr, Katarzyna Niespodziana, Margarete Focke-Tejkl, Birgit Linhart, Rudolf Valenta
    Pages 121-140
  10. Sabine Flicker, Elisabeth Gadermaier, Christoph Madritsch, Rudolf Valenta
    Pages 141-159
  11. Ulrike Baranyi, Martina Gattringer, Rudolf Valenta, Thomas Wekerle
    Pages 161-179
  12. Back Matter
    Pages 181-182

About this book


The pathomechanisms of allergy are quite well investigated and the disease-causing allergens are characterized in great detail down to their molecular structures. We are thus beginning to see several new strategies for allergen-specific immunotherapy on the horizon, several of which are summarized in this issue. It thus seems that hundred years after the first experimental attempts to “desensitize” hayfever patients we are now capable of developing powerful and rational forms of immunotherapy which hold promise for curing allergy sufferers and eventually may allow real prophylactic vaccination against allergy. It is thus quite possible that allergy may become eradicated similar as certain forms of infectious diseases through vaccination.


IgE-mediated allergy allergen specific immunotherapy diet-specific tolerance promotion engineered food proteins food allergy inflammatory immune response recombinant DNA technology recombinant allergens regulatory T lymphocyte synthetic peptides tolerance induction

Editors and affiliations

  • Rudolf Valenta
    • 1
  • Robert L. Coffman
    • 2
  1. 1.Christian Doppler Laboratory for AllergyMedical University of ViennaViennaAustria
  2. 2.Dynavax TechnologiesBerkeleyUSA

Bibliographic information

  • Book Title Vaccines against Allergies
  • Editors Rudolf Valenta
    Robert L. Coffman
  • Series Title Current Topics in Microbiology and Immunology
  • Series Abbreviated Title Current Topics in Microbiology and Immunology
  • DOI
  • Copyright Information Springer-Verlag Berlin Heidelberg 2011
  • Publisher Name Springer, Berlin, Heidelberg
  • eBook Packages Biomedical and Life Sciences Biomedical and Life Sciences (R0)
  • Hardcover ISBN 978-3-642-20053-3
  • Softcover ISBN 978-3-642-27100-7
  • eBook ISBN 978-3-642-20054-0
  • Series ISSN 0070-217X
  • Series E-ISSN 2196-9965
  • Edition Number 1
  • Number of Pages XI, 182
  • Number of Illustrations 20 b/w illustrations, 0 illustrations in colour
  • Topics Vaccine
  • Buy this book on publisher's site
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