Transgenic Models in Pharmacology

  • Stefan Offermanns
  • Lutz Hein

Part of the Handbook of Experimental Pharmacology book series (HEP, volume 159)

Table of contents

  1. Front Matter
    Pages I-XI
  2. Transgenic Techniques

  3. Molecular Systems

    1. Front Matter
      Pages 31-31
    2. S. Engelhardt, L. Hein
      Pages 33-63
    3. J. Wess, W. Zhang, A. Duttaroy, T. Miyakawa, J. Gomeza, Y. Cui et al.
      Pages 65-93
    4. F. Hofmann, M. Biel, R. Feil, T. Kleppisch
      Pages 95-130
    5. S. Offermanns
      Pages 165-192
    6. O. Brandau, R. Fässler
      Pages 193-225
  4. Nervous System

    1. Front Matter
      Pages 227-227
    2. M. Sendtner
      Pages 285-310
    3. J. E. Pintar, B. L. Kieffer
      Pages 311-342
  5. Cardiovascular System

    1. Front Matter
      Pages 343-343
    2. W. J. Koch, B. C. Blaxall
      Pages 345-367
    3. H. H. Bock, P. May, J. Herz
      Pages 397-421
  6. Immunology/Hematology/Inflammation

    1. Front Matter
      Pages 423-423
    2. B. Isermann, H. Weiler
      Pages 469-508
    3. C. Gachet, B. Hechler, C. Léon, J.-P. Cazenave, F. Lanza
      Pages 509-544
    4. G. Bernhardt, O. Pabst, H. Herbrand, R. Förster
      Pages 545-572
  7. Endocrinology

    1. Front Matter
      Pages 573-573
    2. E. F. Greiner, T. Wintermantel, G. Schütz
      Pages 575-606
    3. M. Poutanen, F.-P. Zhang, S. Rulli, S. Mäkelä, P. Sipilä, J. Toppari et al.
      Pages 607-635
  8. Toxicology

  9. Back Matter
    Pages 661-670

About this book


The aim of this volume is to give up-to-date information on animal models generated by transgenic or gene targeting techniques. Naturally, the focus is on the mouse system. Each chapter has been written by leading experts in the field and gives an overview on existing animal models. This is facilitated by tables, which list the most important genetically engineered animal models and their phenotypes. This book aims at  illustrating the impact of transgenic animal models in the field of Experimental Pharmacology and Toxicology, which includes their role in the understanding of basic cellular mechanisms, the evaluation of potential drug targets or the testing for drug effects.



Adrenergic System Chemokine Gene Knockout Neurotransmitter Transgenic mouse models opioid

Editors and affiliations

  • Stefan Offermanns
    • 1
  • Lutz Hein
    • 2
  1. 1.Pharmakologisches InstitutUniversität HeidelbergHeidelbergGermany
  2. 2.Institut für Pharmakologie und Toxikologie der UniversitätGermany

Bibliographic information

  • DOI
  • Copyright Information Springer-Verlag Berlin Heidelberg 2004
  • Publisher Name Springer, Berlin, Heidelberg
  • eBook Packages Springer Book Archive
  • Print ISBN 978-3-642-62362-2
  • Online ISBN 978-3-642-18934-0
  • Series Print ISSN 0171-2004
  • Series Online ISSN 1865-0325
  • Buy this book on publisher's site
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