Artificial Nucleases

  • Marina A. Zenkova

Part of the Nucleic Acids and Molecular Biology book series (NUCLEIC, volume 13)

Table of contents

  1. Front Matter
    Pages I-XVI
  2. Valentin V. Vlassov, Marina A. Zenkova
    Pages 1-2
  3. N. H. Williams
    Pages 3-17
  4. R. T. Raines
    Pages 19-32
  5. V. V. Vlassov, A. V. Vlassov
    Pages 49-60
  6. A. Dallas, A. V. Vlassov, S. A. Kazakov
    Pages 61-88
  7. M. Iyo, H. Kawasaki, M. Miyagishi, K. Taira
    Pages 89-109
  8. I. L. Kuznetsova, V. N. Sil’nikov
    Pages 111-128
  9. S. Verma, S. G. Srivatsan, C. Madhavaiah
    Pages 129-150
  10. N. L. Mironova, D. V. Pyshnyi, E. M. Ivanova
    Pages 151-172
  11. A. Kuzuya, R. Mizoguchi, M. Komiyama
    Pages 173-187
  12. J.-C. Francois, M. Faria, D. Perrin, C. Giovannangeli
    Pages 223-242
  13. A. S. Boutorine, P. B. Arimondo
    Pages 243-268
  14. P. E. Vorobjev, V. F. Zarytova
    Pages 269-287
  15. Back Matter
    Pages 289-292

About this book



The development of agents capable of cleaving RNA and DNA has attracted considerable attention of researchers in the last few years, because of their application in biotechnology and pharmacology. Artificial nucleases are rationally designed to imitate the active centers of natural enzymes by simple structures possessing minimal sets of the most important characteristics that are essential for catalysis. Being less efficient and specific than natural enzymes, the primitive mimics are smaller, more robust and able to function in a broad range of conditions.

The authors of the present volume summarize the state-of-the-art in the rapidly developing field of artificial nucleases. The chapters deal with mechanisms of RNA and DNA cleavage by chemical agents and natural enzymes, development of new nucleic acid-cleaving agents, applications of artificial nucleases, and design of oligonucleotide conjugates with RNA- and DNA-cleaving agents.


Catalysis Cleavage Conjugates DNA Enzyme mimics Nucleotide RNA biotechnology enzymes

Editors and affiliations

  • Marina A. Zenkova
    • 1
  1. 1.Novosibirsk Institute of Bioorganic ChemistryNovosibirskRussia

Bibliographic information

  • DOI
  • Copyright Information Springer-Verlag Berlin Heidelberg 2004
  • Publisher Name Springer, Berlin, Heidelberg
  • eBook Packages Springer Book Archive
  • Print ISBN 978-3-642-62139-0
  • Online ISBN 978-3-642-18510-6
  • Series Print ISSN 0933-1891
  • Buy this book on publisher's site
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