© 2011

The Human Brain

Prenatal Development and Structure


Table of contents

  1. Front Matter
    Pages i-xii
  2. Miguel Marín-Padilla
    Pages 1-4
  3. Miguel Marín-Padilla
    Pages 11-34
  4. Miguel Marín-Padilla
    Pages 121-123
  5. Miguel Marín-Padilla
    Pages 125-136
  6. Miguel Marín-Padilla
    Pages 137-142
  7. Back Matter
    Pages 143-145

About this book


This book is unique among the current literature in that it systematically documents the prenatal structural development of the human brain. It is based on lifelong study using essentially a single staining procedure, the classic rapid Golgi procedure, which ensures an unusual and desirable uniformity in the observations. The book is amply illustrated with 81 large, high-quality color photomicrographs never previously reproduced. These photomicrographs, obtained at 6, 7, 11, 15, 18, 20, 25, 30, 35, and 40 weeks of gestation, offer a fascinating insight into the sequential prenatal development of neurons, blood vessels, and glia in the human brain.


Human Cerebral Cortex Human Cerebral Cortex Neurons, blood vessels and glia developments Neurons, blood vessels and glia developments Prenatal Development Prenatal Development Structure Structure The rapid Golgi method The rapid Golgi method

Authors and affiliations

  1. 1.WoodburyUSA

About the authors

Dr. Miguel Marín-Padilla is Professor Emeritus of Pathology and of Pediatrics at Dartmouth Medical School (Hanover, New Hampshire, USA). He obtained his Medical Degree in Spain (Granada University, 1955), practice Pediatrics for one year but interested in pediatric research immigrate to USA (1956). In USA, he completed Clinical Internship and several years of Pathology Residencies (Mallory Institute of Pathology, Boston), with emphasis in both Developmental and Pediatric Pathology (1957-1961) and was Teaching Fellow in Pathology in both Boston and Harvard Medical Schools (1960-62). He pursued an Academic Career, from Instructor to full Professor in both Pathology and Pediatrics at Dartmouth Medical School (1962-2000). He did a Special Neurohistology Fellowships at the Cajal Institute (Madrid) to study Cajal old Golgi preparations and learn the method (1966-67) and was Visiting Neuroscientist at University of Alcalá de Henares (Spain, 1994) and at the Mayo Clinic (1999). His research efforts has resulted in 180 publications, including abstracts, peer review papers, collaborative works, chapters in books and books. His developmental studies are recognized the world over and he has received various honors for his teaching and for his research efforts, the most notable are:Alpha Omega Alpha (USA Honor Medical Society, 1981); Best teacher award (1988,1996) and Faculty Speaker at Commencements (1985, 1991) at Dartmouth Medical School; Cajal Medal (USA Cajal Club, 1990); Gold Medal ‘Aureliano Maestre de San Juan’ of the University of Granada (1997), Honor Member of the Spanish Neurology (1987) and Pediatric Neurology Societies (2000), The Jacod Javist Neuroscience Investigator Award (USA, 1989), Honor Member of the Royal Academy of Medicine (Murcia, 2001), the Gold Medal of the Community of Murcia (2001) and has been a Candidate to the Principe de Asturias in Sciences (2002), “The Miguel Marín-Padilla Award, Excellence in Pathology”. Annual Lectureship and Award. Dartmouth Medical School (2006). His research has been supported by Grants of the U.S. National Institute of Health from 1962 to 1999.

Bibliographic information

  • Book Title The Human Brain
  • Book Subtitle Prenatal Development and Structure
  • Authors Miguel Marín-Padilla
  • DOI
  • Copyright Information Springer-Verlag GmbH Berlin Heidelberg 2011
  • Publisher Name Springer, Berlin, Heidelberg
  • eBook Packages Medicine Medicine (R0)
  • Hardcover ISBN 978-3-642-14723-4
  • Softcover ISBN 978-3-662-51996-7
  • eBook ISBN 978-3-642-14724-1
  • Edition Number 1
  • Number of Pages XII, 145
  • Number of Illustrations 0 b/w illustrations, 0 illustrations in colour
  • Topics Neuroradiology
  • Buy this book on publisher's site
Industry Sectors
Health & Hospitals


From the reviews:

“Marín-Padilla’s recent monograph will be of great significance for anyone now embarking on the study of cortical development; it is an obligatory source for anyone working in the field of cortical development with an interest in clinical translation. … His presentations were colorful and elegant, using forceful, captivating and entertaining rhetoric. … great value for future generations of paediatric neuropathologists and researchers … . I enjoyed reading the book … . I envisage keeping this book on a shelf in my laboratory … .” (Zoltán Molnár, Brain, Vol. 134, 2011)

“In 143 beautifully written and illustrated pages, the author presents the organization and development of the human and feline motor cortex, as well as personal reflections on his scientific quest with the Golgi stain. … This book is relevant to neuropathologists because it presents from the 3-dimensional perspective the normative organization of the developing human cortex as a basis for interpretation of the multiple destructive and malformative disorders of the embryo and fetus. The book is relevant to clinicians … . ” (Hannah C. Kinney, Journal of Neuropathology and Experimental Neurology, Vol. 71 (2), February, 2012)