© 2010

Diverse Effects of Hypoxia on Tumor Progression

  • M. Celeste Simon


  • Hypoxia, defined as reduced oxygen tension, is a common physiological phenomenon in both normal embryonic development and malignancy progression Hypoxia promotes cancer progression by regulating various aspects of cancer biology, including radiotherapy resistance, metabolism, angiogenesis and invasion/migration


Part of the Current Topics in Microbiology and Immunology book series (CT MICROBIOLOGY, volume 345)

Table of contents

  1. Front Matter
    Pages i-x
  2. Amato J. Giaccia, Ernestina Schipani
    Pages 31-45
  3. Robert McCormick, Francesca M. Buffa, Jiannis Ragoussis, Adrian L. Harris
    Pages 47-70
  4. Annelies Quaegebeur, Peter Carmeliet
    Pages 71-103
  5. Hongxia Z. Imtiyaz, M. Celeste Simon
    Pages 105-120
  6. Helene Rundqvist, Randall S. Johnson
    Pages 121-139
  7. Back Matter
    Pages 141-143

About this book


Solid tumors frequently contain areas of oxygen deprivation (hypoxia) due to rapid cell proliferation and/or vascular insufficiency. The presence of hypoxic domains typically correlates with poor patient prognosis, due to the relative resistance of hypoxic cells to conventional cancer therapies and effects of O2 availability on disease progression. The response of malignant cells to hypoxia has been the focus of intense research over the last decade. In this issue of Current Topics in Microbiology and Immunology, the authors present articles describing the impact of hypoxia on components of the tumor microenvironment (such as endothelial cells, inflammatory cells, and tumor associated fibroblasts), the expression of unique microRNAs, tumor cell differentiation status, and metastasis. Each review article describes the state of the field studying these topics, and poses important questions for the future. The overall goal is to depict tumor phenotypes and associated molecular pathways to be exploited in the development of novel therapeutics to be used against a broad spectrum of human cancers.


angiogenesis biology cancer stem cell maintenance cancer-associated fibroblasts carcinoma cells glioblastoma multiforme hypoxia-inducible factors metabolism microRNAs tissue tumor progression

Editors and affiliations

  • M. Celeste Simon
    • 1
  1. 1.MedicineUniversity of Pennsylvania School ofPhiladelphiaUSA

Bibliographic information

  • Book Title Diverse Effects of Hypoxia on Tumor Progression
  • Editors M. Celeste Simon
  • Series Title Current Topics in Microbiology and Immunology
  • Series Abbreviated Title Current Topics in Microbiology and Immunology
  • DOI
  • Copyright Information Springer-Verlag Berlin Heidelberg 2010
  • Publisher Name Springer, Berlin, Heidelberg
  • eBook Packages Biomedical and Life Sciences Biomedical and Life Sciences (R0)
  • Hardcover ISBN 978-3-642-13328-2
  • Softcover ISBN 978-3-642-26484-9
  • eBook ISBN 978-3-642-13329-9
  • Series ISSN 0070-217X
  • Edition Number 1
  • Number of Pages X, 146
  • Number of Illustrations 0 b/w illustrations, 0 illustrations in colour
  • Topics Cancer Research
    Human Physiology
  • Buy this book on publisher's site
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