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Varicella-zoster Virus

  • Allison Abendroth
  • Ann M. Arvin
  • Jennifer F. Moffat

Part of the Current Topics in Microbiology and Immunology book series (CT MICROBIOLOGY, volume 342)

Table of contents

  1. Front Matter
    Pages i-xiv
  2. Jeffrey I. Cohen
    Pages 1-14
  3. Judith Breuer
    Pages 15-42
  4. Jennifer F. Moffat, Rebecca J. Greenblatt
    Pages 67-77
  5. Teri K. Kenyon, Charles Grose
    Pages 99-111
  6. Charles Grose, John E. Carpenter, Wallen Jackson, Karen M. Duus
    Pages 113-128
  7. Yasuko Mori, Tomohiko Sadaoka
    Pages 147-154
  8. Allison Abendroth, Paul R. Kinchington, Barry Slobedman
    Pages 155-171
  9. Ann M. Arvin, Jennifer F. Moffat, Marvin Sommer, Stefan Oliver, Xibing Che, Susan Vleck et al.
    Pages 189-209
  10. Megan Steain, Barry Slobedman, Allison Abendroth
    Pages 211-228
  11. Don Gilden, Randall J. Cohrs, Ravi Mahalingam, Maria A. Nagel
    Pages 243-253
  12. Wayne L. Gray
    Pages 291-308
  13. Ravi Mahalingam, Ilhem Messaoudi, Don Gilden
    Pages 309-321
  14. Adriana Weinberg, Myron J. Levin
    Pages 341-357
  15. Anne A. Gershon, Michael D. Gershon
    Pages 359-372
  16. Back Matter
    Pages 373-377

About this book

Introduction

Varicella-zoster virus is a common human pathogen that causes varicella (chickenpox), establishes latency in sensory nerve ganglia and can reactivate many years later as herpes zoster. Although the VZV genome is the smallest of the human herpesviruses, VZV genes encode at least 70 proteins. Molecular epidemiologic approaches based on genomic sequencing have documented the global distribution of VZV in distinct clades that reflect patterns of human migration. Contemporary molecular methods are making it possible to dissect how VZV gene products support the viral life cycle, including those that are necessary for viral replication, virion assembly and egress as well as those that permit take over of the host cell by modulating cell cycle regulation, survival and intrinsic antiviral responses. Progress is also being made in understanding the events in VZV pathogenesis and the viral tropisms for keratinocytes, T cells, dendritic cells and neurons during primary infection, latency and reactivation and the innate and adaptive host responses that modulate these events. New insights about molecular virology and pathogenesis have emerged from comparative studies of VZV and simian varicella virus. VZV is the only human herpesvirus for which vaccines to prevent both primary and recurrent infection are approved and VZV vaccines have had significant public health benefits. These achievements and new directions that are unfolding are described in this review of VZV basic and clinical research

Keywords

VZV ORF66 VZV genome VZV infection VZV replication dendritic cells herpes zoster infections nosocomial spread post-herpetic neuralgia protein simian varicella virus virology virus

Editors and affiliations

  • Allison Abendroth
    • 1
  • Ann M. Arvin
    • 2
  • Jennifer F. Moffat
    • 3
  1. 1.Department of Infectious Diseases and Im, Head, VZV Research LaboratoryUniversity of SydneySydneyAustralia
  2. 2.School of Medicine, Dept. Microbiology & ImmunologyStanford UniversityStanfordUSA
  3. 3.2215 Weiskotten HallUpstate Medical UniversitySyracuseUSA

Bibliographic information

  • DOI https://doi.org/10.1007/978-3-642-12728-1
  • Copyright Information Springer-Verlag Berlin Heidelberg 2010
  • Publisher Name Springer, Berlin, Heidelberg
  • eBook Packages Biomedical and Life Sciences
  • Print ISBN 978-3-642-12727-4
  • Online ISBN 978-3-642-12728-1
  • Series Print ISSN 0070-217X
  • Buy this book on publisher's site
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