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Immunological Synapse

  • Takashi Saito
  • Facundo D. Batista
Book

Part of the Current Topics in Microbiology and Immunology book series (CT MICROBIOLOGY, volume 340)

Table of contents

  1. Front Matter
    Pages i-xv
  2. Philipp Eissmann, Daniel M. Davis
    Pages 63-79
  3. Tadashi Yokosuka, Takashi Saito
    Pages 81-107
  4. Antonella Viola, Rita Lucia Contento, Barbara Molon
    Pages 109-122
  5. Nicholas R. J. Gascoigne, Tomasz Zal, Pia P. Yachi, John A. H. Hoerter
    Pages 171-189
  6. Salvatore Valitutti, Loïc Dupré
    Pages 209-228
  7. Peter Reichardt, Bastian Dornbach, Matthias Gunzer
    Pages 229-249
  8. Back Matter
    Pages 251-255

About this book

Introduction

The proper physiological functioning of most eukaryotic cells requires their assembly into multi-cellular tissues that form organized organ systems. Cells of the immune system develop in bone marrow and lymphoid organs, but as the cells mature they leave these organs and circulate as single cells. Antigen receptors (TCRs) of T cells search for membrane MHC proteins that are bound to peptides derived from infectious pathogens or cellular transformations. The detection of such speci?c peptide–MHC antigens initiates T cell activation, adhesion, and immune-effectors functions. Studies of normal and transformed T cell lines and of T cells from transgenic mice led to comprehensive understanding of the mole- lar basis of antigen-receptor recognition and signaling. In spite of these remarkable genetic and biochemical advances, other key physiological mechanisms that par- cipate in sensing and decoding the immune context to induce the appropriate cellular immune responses remain unresolved. TCR recognition is tightly regulated to trigger sensitive but balanced T cell responses that result in the effective elimination of the pathogens while minimizing collateral damage to the host. The sensitivity of TCR recognition has to be properly tempered to prevent unintended activation by self-peptide–MHC complexes that cause autoimmune diseases. It is likely that once the TCR is engaged by a peptide– MHC and TCR signaling begins, additional regulatory mechanisms, involving other receptors, would increase the ?delity of the response.

Keywords

Antigen B-cell receptor T-cell activation antigen encounter antigen recognition cell-cell communication co-receptors immunological synapse formation innate immunity lymphotrophic viruses natural killer cells

Editors and affiliations

  • Takashi Saito
    • 1
  • Facundo D. Batista
    • 2
  1. 1.Allergy & ImmunologyRIKEN Research Center forokohama City, KanagawaJapan
  2. 2.London Research InstituteCancer Research UKLondonUnited Kingdom

Bibliographic information

  • DOI https://doi.org/10.1007/978-3-642-03858-7
  • Copyright Information Springer-Verlag Berlin Heidelberg 2010
  • Publisher Name Springer, Berlin, Heidelberg
  • eBook Packages Biomedical and Life Sciences
  • Print ISBN 978-3-642-03857-0
  • Online ISBN 978-3-642-03858-7
  • Series Print ISSN 0070-217X
  • Buy this book on publisher's site
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