Molecular Biology of the SARS-Coronavirus

  • Sunil K. Lal

Table of contents

  1. Front Matter
    Pages i-xiii
  2. Viral Entry

  3. Structures Involved in Viral Replication and Gene Expression

  4. Viral Proteins

    1. Front Matter
      Pages 74-74
    2. Rachel Ulferts, Isabelle Imbert, Bruno Canard, John Ziebuhr
      Pages 75-98
    3. Isabelle Imbert, Rachel Ulferts, John Ziebuhr, Bruno Canard
      Pages 99-114
    4. Scott R. Schaecher, Andrew Pekosz
      Pages 153-166
  5. Viral pathogenesis and host immune response

    1. Front Matter
      Pages 194-194
    2. Timothy P. Sheahan, Ralph S. Baric
      Pages 195-230
    3. Claudia Diemer, Martha Schneider, Hermann M. Schätzl, Sabine Gilch
      Pages 231-245
    4. Wei Zuo, Xingang Zhao, Ye-Guang Chen
      Pages 247-258
    5. Chris Ka-fai Li, Xiaoning Xu
      Pages 259-278
    6. T. Narasaraju, P. L. Soong, J. ter Meulen, J. Goudsmit, Vincent T. K. Chow
      Pages 289-304
  6. Back Matter
    Pages 323-328

About this book


SARS was the ?rst new plague of the twenty-?rst century. Within months, it spread worldwide from its “birthplace” in Guangdong Province, China, affecting over 8,000 people in 25 countries and territories across ?ve continents. SARS exposed the vulnerability of our modern globalised world to the spread of a new emerging infection. SARS (or a similar new emerging disease) could neither have spread so rapidly nor had such a great global impact even 50 years ago, and arguably, it was itself a product of our global inter-connectedness. Increasing af?uence and a demand for wild-game as exotic food led to the development of large trade of live animal and game animal markets where many species of wild and domestic animals were co-housed, providing the ideal opportunities for inter-species tra- mission of viruses and other microbes. Once such a virus jumped species and attacked humans, the increased human mobility allowed the virus the opportunity for rapid spread. An infected patient from Guangdong who stayed for one day at a hotel in Hong Kong led to the transmission of the disease to 16 other guests who travelled on to seed outbreaks of the disease in Toronto, Singapore, and Vietnam, as well as within Hong Kong itself. The virus exploited the practices used in modern intensive care of patients with severe respiratory disease and the weakness in infection control practices within our health care systems to cause outbreaks within hospitals, further amplifying the spread of the disease. Health-care itself has become a two-edged sword.


Epidemic Species barrier Viral transmission gene expression genes molecular biology molecular mechanisms

Editors and affiliations

  • Sunil K. Lal
    • 1
  1. 1.Engineering & BiotechnologyInternational Centre for GeneticNew DelhiIndia

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