Postnatal Development of the Human Hippocampal Formation

  • Ricardo Insausti
  • Sandra Cebada-Sánchez
  • Pilar Marcos

Part of the Advances in Anatomy, Embryology and Cell Biology book series (ADVSANAT, volume 206)

Table of contents

  1. Front Matter
    Pages i-xvi
  2. Ricardo Insausti, Sandra Cebada-Sánchez, Pilar Marcos
    Pages 1-3
  3. Ricardo Insausti, Sandra Cebada-Sánchez, Pilar Marcos
    Pages 5-7
  4. Ricardo Insausti, Sandra Cebada-Sánchez, Pilar Marcos
    Pages 9-26
  5. Ricardo Insausti, Sandra Cebada-Sánchez, Pilar Marcos
    Pages 27-60
  6. Ricardo Insausti, Sandra Cebada-Sánchez, Pilar Marcos
    Pages 61-69
  7. Ricardo Insausti, Sandra Cebada-Sánchez, Pilar Marcos
    Pages 71-78
  8. Back Matter
    Pages 79-89

About this book


The postnatal development of the human hippocampal formation (HF) is subject of increasing interest due to its implication in important pathologies that hamper the normal development of children. In this work, the authors present a glimpse of the main events that constitute important milestones in the development and shaping of some of the most important psychological capabilities such as autobiographical memory. Although they examined some cases in the last trimester of gestation, their description starts at birth, around 40 gestational weeks. Serial sections with thionin for Nissl analysis revealed that all fields of the HF were present and identifiable at birth. However, the relative growth of the cortical mantle was much higher relative to the HF. The main structural changes took place during the first postnatal year, in particular in the dentate gyrus and in the entorhinal cortex. At subsequent ages, a growth in size was noted in all components of the HF. This growth was more evident at the body and tail of the hippocampus, as evidenced by measurements of the neuroanatomical series. In addition, the authors examined in some cases the MRI appearance of the HF at different postnatal ages obtained by post-mortem imaging. MRI neuroanatomical series provided anatomically identified landmarks useful for the MRI identification of different components of the HF during postnatal development.


Neurobiology anatomy attention deficit autobiographical memory bipolar disorder development epilepsy hyperactivity disorder memory maturation

Authors and affiliations

  • Ricardo Insausti
    • 1
  • Sandra Cebada-Sánchez
    • 2
  • Pilar Marcos
    • 3
  1. 1.CRIBUniversidad Castilla-La ManchaAlbaceteSpain
  2. 2.CRIBUniversidad Castilla-La ManchaAlbaceteSpain
  3. 3.CRIBUniversidad Castilla-La ManchaAlbaceteSpain

Bibliographic information

  • DOI
  • Copyright Information Springer-Verlag Berlin Heidelberg 2010
  • Publisher Name Springer, Berlin, Heidelberg
  • eBook Packages Biomedical and Life Sciences
  • Print ISBN 978-3-642-03660-6
  • Online ISBN 978-3-642-03661-3
  • Series Print ISSN 0301-5556
  • Buy this book on publisher's site
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