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miRNA Regulation of the Translational Machinery

  • Robert E. Rhoads

Part of the Progress in Molecular and Subcellular Biology book series (PMSB, volume 50)

Table of contents

  1. Front Matter
    Pages 1-9
  2. Marc R. Fabian, Thomas R. Sundermeier, Nahum Sonenberg
    Pages 1-20
  3. Benjamin A. Hurschler, Xavier C. Ding, Helge Großhans
    Pages 21-40
  4. Aida Martínez-Sánchez, Fátima Gebauer
    Pages 59-70
  5. Traude H. Beilharz, David T. Humphreys, Thomas Preiss
    Pages 99-112
  6. Back Matter
    Pages 1-3

About this book

Introduction

The silencing of gene expression by small interfering RNAs has been recognized for only a relatively short time, but this has transformed our understanding of both transcriptional and post-transcriptional gene regulatory mechanisms. Multiple pathways culminate in formation of an RNA-induced silencing complex (RISC) containing a member of the Argonaute protein family bound to a 22-nt RNA strand that interacts with a target mRNA or gene through Watson-Crick base pairing. One consequence is mRNA-specific inhibition of protein synthesis. Evidence has been presented for diverse mechanisms, but there is not universal agreement in the field of how RISCs affect the translational machinery. The chapters collected in this volume represent contribution by leaders in the search to understand how miRNAs affect translation. They include chapters representing work in plants and Caenorhabditis elegans, the biological systems that originally led to the discovery of small interfering RNAs, but also include chapters on mammalian systems, with special emphasis on regulation of a key tumor suppressor and a protein that restricts human immunodeficiency virus 1 (HIV-1).

Keywords

RNA Translation enzymes gene expression genes miRNAs regulation transcription

Editors and affiliations

  • Robert E. Rhoads
    • 1
  1. 1.Health Science Center, Dept. Biochemistry & Molecular BiologyLouisiana State UniversityShreveportUSA

Bibliographic information

  • DOI https://doi.org/10.1007/978-3-642-03103-8
  • Copyright Information Springer-Verlag Berlin Heidelberg 2010
  • Publisher Name Springer, Berlin, Heidelberg
  • eBook Packages Biomedical and Life Sciences
  • Print ISBN 978-3-642-03102-1
  • Online ISBN 978-3-642-03103-8
  • Series Print ISSN 0079-6484
  • Buy this book on publisher's site
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