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Single Molecule Spectroscopy in Chemistry, Physics and Biology

Nobel Symposium

  • Astrid Gräslund
  • Rudolf Rigler
  • Jerker Widengren
Book

Part of the Springer Series in Chemical Physics book series (CHEMICAL, volume 96)

Table of contents

  1. Front Matter
    Pages I-XXI
    PDF

  2. Introductory Lecture: Molecular Dynamics of Single Molecules

    1. Front Matter
      Pages 1-1
      PDF
    2. How Biomolecular Motors Work: Synergy Between Single Molecule Experiments and Single Molecule Simulations
      Martin Karplus, Jingzhi Pu
      Pages 3-22

  3. Detection of Single Molecules and Single Molecule Processes

    1. Front Matter
      Pages 24-24
      PDF
    2. Single-Molecule Optical Spectroscopy and Imaging: From Early Steps to Recent Advances
      William E. Moerner
      Pages 25-60
    3. Single Molecules as Optical Probes for Structure and Dynamics
      Michel Orrit
      Pages 61-76
    4. FCS and Single Molecule Spectroscopy
      Rudolf Rigler
      Pages 77-103

  4. Fluorescence-Correlation Spectroscopy

    1. Front Matter
      Pages 106-106
      PDF
    2. Single Molecule Spectroscopy Illuminating the Molecular Dynamics of Life
      Watt W. Webb
      Pages 107-117
    3. Chemical Fluxes in Cellular Steady States Measured by Fluorescence Correlation Spectroscopy
      Hong Qian, Elliot L. Elson
      Pages 119-137
    4. In Vivo Fluorescence Correlation and Cross-Correlation Spectroscopy
      Jörg Mütze, Thomas Ohrt, Zdeněk Petrášek, Petra Schwille
      Pages 139-154
    5. Fluorescence Flicker as a Read-out in FCS: Principles, Applications and Further Developments
      Jerker Widengren
      Pages 155-172

  5. Quantum Dots and Single Molecule Behaviour

    1. Front Matter
      Pages 174-174
      PDF
    2. Development of Nanocrystal Molecules for Plasmon Rulers and Single Molecule Biological Imaging
      A. P. Alivisatos
      Pages 175-186
    3. Size-Minimized Quantum Dots for Molecular and Cellular Imaging
      Andrew M. Smith, Mary M. Wen, May D. Wang, Shuming Nie
      Pages 187-201
    4. Mapping Transcription Factors on Extended DNA: A Single Molecule Approach
      Yuval Ebenstein, Natalie Gassman, Shimon Weiss
      Pages 203-216

  6. Molecular Motion of Contractile Elements and Polymer Formation

    1. Front Matter
      Pages 218-218
      PDF
    2. Single Molecule Measurement, a Tool for Exploring the Dynamic Mechanism of Biomolecules
      Toshio Yanagida
      Pages 219-236
    3. Viral DNA Packaging: One Step at a Time
      Carlos Bustamante, Jeffrey R. Moffitt
      Pages 237-269
    4. Chemo-Mechanical Coupling in the Rotary Molecular Motor F1-ATPase
      Kengo Adachi, Shou Furuike, Mohammad Delawar Hossain, Hiroyasu Itoh, Kazuhiko Kinosita Jr., Yasuhiro Onoue et al.
      Pages 271-285

  7. Force and Multiparameter Spectroscopy on Functional Active Proteins

    1. Front Matter
      Pages 288-288
      PDF
    2. Mechanoenzymatics and Nanoassembly of Single Molecules
      Elias M. Puchner, Hermann E. Gaub
      Pages 289-303
    3. Single Cell Physiology
      Pierre Neveu, Deepak Kumar Sinha, Petronella Kettunen, Sophie Vriz, Ludovic Jullien, David Bensimon
      Pages 305-316
    4. Force-Clamp Spectroscopy of Single Proteins
      Julio M Fernandez, Sergi Garcia-Manyes, Lorna Dougan
      Pages 317-335
    5. Unraveling the Secrets of Bacterial Adhesion Organelles Using Single-Molecule Force Spectroscopy
      Ove Axner, Oscar Björnham, Mickaël Castelain, Efstratios Koutris, Staffan Schedin, Erik Fällman et al.
      Pages 337-362

  8. Nanoscale Microscopy and High Resolution Imaging

    1. Front Matter
      Pages 364-364
      PDF
    2. Far-Field Optical Nanoscopy
      Stefan W. Hell
      Pages 365-398
    3. Sub-Diffraction-Limit Imaging with Stochastic Optical Reconstruction Microscopy
      Mark Bates, Bo Huang, Michael J. Rust, Graham T. Dempsey, Wenqin Wang, Xiaowei Zhuang
      Pages 399-415
    4. Assessing Biological Samples with Scanning Probes
      A. Engel
      Pages 417-431

  9. Single Molecule Microscopy in Individual Cells

    1. Front Matter
      Pages 434-434
      PDF
    2. Enzymology and Life at the Single Molecule Level
      X. Sunney Xie
      Pages 435-448
    3. Controlling Chemistry in Dynamic Nanoscale Systems
      Aldo Jesorka, Ludvig Lizana, Zoran Konkoli, Ilja Czolkos, Owe Orwar
      Pages 449-468

  10. Catalysis of Single Enzyme Molecules

    1. Front Matter
      Pages 470-470
      PDF
    2. Single-Molecule Protein Conformational Dynamics in Enzymatic Reactions
      H. Peter Lu
      Pages 471-494
    3. Watching Individual Enzymes at Work
      Kerstin Blank, Susana Rocha, Gert De Cremer, Maarten B. J. Roeffaers, Hiroshi Uji-i, Johan Hofkens
      Pages 495-511
    4. The Influence of Symmetry on the Electronic Structure of the Photosynthetic Pigment-Protein Complexes from Purple Bacteria
      Martin F. Richter, Jürgen Baier, Richard J. Cogdell, Silke Oellerich, Jürgen Köhler
      Pages 513-533

  11. Fields and Outlook

    1. Front Matter
      Pages 536-536
      PDF
    2. Exploring Nanostructured Systems with Single-Molecule Probes: From Nanoporous Materials to Living Cells
      Christoph Bräuchle
      Pages 537-551
    3. Gene Regulation: Single-Molecule Chemical Physics in a Natural Context
      Peter G. Wolynes
      Pages 553-560
  12. Back Matter
    Pages 561-572
    PDF

About this book

Introduction

Written by the leading experts in the field, this book describes the development and current state-of-the-art in single molecule spectroscopy. The application of this technique, which started 1989, in physics, chemistry and biosciences is displayed.

Keywords

Dynamics of single molecules Fluorescence correlation spectroscopy Quantum dots Single molecule spectroscopy Spectroscopy in nanoscience diffraction imaging microscopy molecule nanostructure quantum dot spectroscopy

Editors and affiliations

  • Astrid Gräslund
    • 1
  • Rudolf Rigler
    • 2
  • Jerker Widengren
    • 3
  1. 1.Dept. BiophysicsStockholm UniversityStockholmSweden
  2. 2.St. SulpiceSwitzerland
  3. 3.Dept. Biomolecular PhysicsRoyal Institute of Technology (KTH)StockholmSweden

Bibliographic information

  • DOI https://doi.org/10.1007/978-3-642-02597-6
  • Copyright Information Springer-Verlag Berlin Heidelberg 2010
  • Publisher Name Springer, Berlin, Heidelberg
  • eBook Packages Physics and Astronomy
  • Print ISBN 978-3-642-02596-9
  • Online ISBN 978-3-642-02597-6
  • Series Print ISSN 0172-6218
  • Buy this book on publisher's site
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