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HIV Interactions with Host Cell Proteins

  • Paul Spearman
  • Eric O. Freed
Book

Part of the Current Topics in Microbiology and Immunology book series (CT MICROBIOLOGY, volume 339)

Table of contents

  1. Front Matter
    Pages 1-9
  2. Anna Maria Niewiadomska, Xiao-Fang Yu
    Pages 1-25
  3. Byeongwoon Song
    Pages 47-66
  4. Hin Chu, Jaang-Jiun Wang, Paul Spearman
    Pages 67-84
  5. Cindy M. Danielson, Thomas J. Hope
    Pages 103-123
  6. Manuel Llano, James Morrison, Eric M. Poeschla
    Pages 125-146
  7. Vicente Planelles, Serge Benichou
    Pages 177-200
  8. Back Matter
    Pages 1-4

About this book

Introduction

The study of viruses necessarily involves dissecting the intimate details of cellular pathways. Viruses have often been employed as tools in studying cellular pathways, as was done by early retrovirologists such as Peyton Rous in attempting to understand the mechanism of cellular transformation and oncogenesis. On the other side of the coin, virologists seek to de?ne those cellular elements interacting intimatelywiththeir virus ofinterestinorder to better understand viral replication itself, and in some cases to develop antiviral strategies. It is in the intersection of virology and cell biology that many of us ?nd the most rewarding aspects of our research. When a new discovery yields insights into basic cellular mechanisms and presents new targets for int- vention to ?ght a serious pathogen, the impact can be high and the excitement intense. HIV has been no exception to the rule that viruses reveal many basic aspects of cellular biology. In recent years, in part because of the importance of HIV as a major cause of human suffering, numerous cellular processes have been elucidated through work on processes or proteins of this human retrovirus. The excitement in this ?eld is especially well illustrated by the discovery of new innate means of resisting viral replication, such as the work on APOBEC3G, TRIM5a, and BST-2/ tetherin presented in this volume.

Keywords

AIDS HIV HIV-1 replication cellular vesicular trafficking imaging retroviral replication tetherin tetraspanins transcriptional coactivator vaccine viral immune evasion viral infectivity factor (Vif) virus

Editors and affiliations

  • Paul Spearman
    • 1
  • Eric O. Freed
    • 2
  1. 1.School of Medicine, Dept. PediatricsEmory UniversityAtlantaUSA
  2. 2.HIV Drug Resistance ProgramNational Cancer Institute-FrederickFrederickUSA

Bibliographic information

  • DOI https://doi.org/10.1007/978-3-642-02175-6
  • Copyright Information Springer-Verlag Berlin Heidelberg 2009
  • Publisher Name Springer, Berlin, Heidelberg
  • eBook Packages Biomedical and Life Sciences
  • Print ISBN 978-3-642-02174-9
  • Online ISBN 978-3-642-02175-6
  • Series Print ISSN 0070-217X
  • Buy this book on publisher's site
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