Sex Hormones and Immunity to Infection

  • Sabra L. Klein
  • Craig Roberts

Table of contents

  1. Front Matter
    Pages i-x
  2. S. Ansar Ahmed, Ebru Karpuzoglu, Deena Khan
    Pages 19-51
  3. Susan Kovats, Esther Carreras, Hemant Agrawal
    Pages 53-91
  4. Sabra L. Klein, Sally Huber
    Pages 93-122
  5. Jennifer A. Rettew, Ian Marriott, Yvette M. Huet
    Pages 123-146
  6. James Alexander, Karen Irving, Heidi Snider, Abhay Satoskar
    Pages 147-186
  7. Galileo Escobedo, Marco A. De León-Nava, Jorge Morales-Montor
    Pages 187-204
  8. Julia Szekeres-Bartho, Beata Polgar
    Pages 205-226
  9. Fiona L. Henriquez, Fiona M. Menzies, Craig W. Roberts
    Pages 227-256
  10. Patti Gravitt, Khalil Ghanem
    Pages 257-279
  11. Allison C. Brown, William J. Moss
    Pages 281-302
  12. Craig W. Roberts, Sabra L. Klein
    Pages 303-311
  13. Back Matter
    Pages 313-319

About this book


Why sex matters

Among human and nonhuman animals, the prevalence and intensity of infection typically is higher in males than females and may reflect differences in exposure as well as susceptibility to pathogens. Elevated immunity among females is a double-edged sword in which it is beneficial against infectious diseases but is detrimental in terms of increased development of autoimmune diseases.

The present book critically reviews the evolutionary origin and the functional mechanisms responsible for sexual dimorphism in response to infection. It emphasizes the value of examining responses in both males and females to improve our understanding about host-pathogen interactions in both sexes.

The contributors are experts in their specific disciplines which range from microbiology and immunology to genetics, pathology, and evolutionary biology.

The book aims at bringing insight to the treatment and management of infectious diseases; it delineates areas where knowledge is lacking and highlights future avenues of research.


autoimmune disease biology development diseases evolution evolutionary biology genetics hormone infection infectious infectious disease infectious diseases microbiology pathology treatment

Editors and affiliations

  • Sabra L. Klein
    • 1
  • Craig Roberts
    • 2
  1. 1.School of Public HealthJohns Hopkins BloombergBaltimoreU.S.A.
  2. 2.Institute for Biomedical SciencesUniversity of StrathclydeGlasgowUnited Kingdom

Bibliographic information

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