© 2009

Molecular Mechanisms of Bacterial Infection via the Gut

  • Chihiro Sasakawa

Part of the Current Topics in Microbiology and Immunology book series (CT MICROBIOLOGY, volume 337)

Table of contents

  1. Front Matter
    Pages i-xi
  2. Yanet Valdez, Rosana B. R. Ferreira, B. Brett Finlay
    Pages 93-127
  3. Sukhadeo B. Barbuddhe, Trinad Chakraborty
    Pages 173-195
  4. Jos P. M. van Putten, Lieke B. van Alphen, Marc M. S. M. Wösten, Marcel R. de Zoete
    Pages 197-229
  5. Hiroshi Ashida, Michinaga Ogawa, Hitomi Mimuro, Chihiro Sasakawa
    Pages 231-255
  6. Back Matter
    Pages 257-260

About this book


Our gut is colonized by numerous bacteria throughout our life, and the gut epithelium is constantly exposed to foreign microbes and dietary antigens. Thus, the gut epithelium acts as a barrier against microbial invaders and is equipped with various innate defense systems. Resident commensal and foreign invading bacteria interact intimately with the gut epithelium and can impact host cellular and innate immune responses. From the perspective of many pathogenic bacteria, the gut epithelium serves as an infectious foothold and port of entry for disseminate into deeper tissues. In some instances when the intestinal defense activity and host immune system become compromised, even commensal and opportunistic pathogenic bacteria can cross the barrier and initiate local and systematic infectious diseases. Conversely, some highly pathogenic bacteria, such as those highlighted in this book, are able to colonize or invade the intestinal epithelium despite the gut barrier function is intact. Therefore, the relationship between the defensive activity of the intestinal epithelium against microbes and the pathogenesis of infective microbes becomes the basis for maintaining a healthy life.

The authors offer an overview of the current topics related to major gastric and enteric pathogens, while highlighting their highly evolved host (human)-adapted infectious processes. Clearly, an in-depth study of bacterial infectious strategies, as well as the host cellular and immune responses, presented in each chapter of this book will provide further insight into the critical roles of the host innate and adaptive immune systems and their importance in determining the severity or completely preventing infectious diseases. Furthermore, under the continuous threat of emerging and re-emerging infectious diseases, the topic of gut-bacteria molecular interactions will provide various clues and ideas for the development of new therapeutic strategies.


Antigen Campylobacter jejuni Helicobacter pylori Listeria Salmonella Shigella Vibrio cholerae Yersinia human gastric pathogens infectious disease tissue

Editors and affiliations

  • Chihiro Sasakawa
    • 1
  1. 1.Institute of Medical ScienceUniversity of TokyoTokyoJapan

Bibliographic information

  • Book Title Molecular Mechanisms of Bacterial Infection via the Gut
  • Editors Chihiro Sasakawa
  • Series Title Current Topics in Microbiology and Immunology
  • Series Abbreviated Title Current Topics Microbiology
  • DOI
  • Copyright Information Springer-Verlag Berlin Heidelberg 2009
  • Publisher Name Springer, Berlin, Heidelberg
  • eBook Packages Biomedical and Life Sciences Biomedical and Life Sciences (R0)
  • Hardcover ISBN 978-3-642-01845-9
  • Softcover ISBN 978-3-642-26112-1
  • eBook ISBN 978-3-642-01846-6
  • Series ISSN 0070-217X
  • Edition Number 1
  • Number of Pages XII, 260
  • Number of Illustrations 9 b/w illustrations, 13 illustrations in colour
  • Topics Immunology
    Medical Microbiology
    Molecular Medicine
  • Buy this book on publisher's site
Industry Sectors
Health & Hospitals