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Lead-Seeking Approaches

  • Matthew M. Hayward
  • J. A. Bikker
  • J. W. Ellingboe
  • K. D. Freeman-Cook
  • A. M. Gilbert
  • R. K. Harrison
  • D. W. Kung
  • C. A. Lipinski
  • J. E. Morin
  • L. S. Narasimhan
  • J. W. Paslay
  • M. Pellecchia

Part of the Topics in Medicinal Chemistry book series (TMC, volume 5)

Table of contents

  1. Front Matter
    Pages i-xiii
  2. Jeff W. Paslay, John E. Morin, Richard K. Harrison
    Pages 25-83
  3. Jack Andrew Bikker, Lakshmi S. Narasimhan
    Pages 85-124
  4. Maurizio Pellecchia
    Pages 125-139
  5. John W. Ellingboe, Adam M. Gilbert
    Pages 175-212
  6. Back Matter
    Pages 213-217

About this book

Introduction

Christopher A. Lipinski: Overview of Hit to Lead: The Medicinal Chemist’s Role from HTS Retest to Lead Optimization Hand Off

Jeff W. Paslay • John E. Morin • Richard K. Harrison: High Throughput Screening in the Twenty - First Century

Jack Andrew Bikker • Lakshmi S.Narasimhan: Lead Discovery Using Virtual Screening

Maurizio Pellecchia: NMR Spectroscopy in Fragment Based Drug Design

Kevin D. Freeman-Cook • Daniel W. Kung: Hit Triage – Medicinal Chemistry Strategies to Improve the Odds of Success in Discovery

John W. Ellingboe • Adam M. Gilbert: Lead Identification

Keywords

chemistry medicinal chemistry nuclear magnetic resonance (NMR) spectroscopy

Editors and affiliations

  • Matthew M. Hayward
    • 1
  • J. A. Bikker
  • J. W. Ellingboe
  • K. D. Freeman-Cook
  • A. M. Gilbert
  • R. K. Harrison
  • D. W. Kung
  • C. A. Lipinski
  • J. E. Morin
  • L. S. Narasimhan
  • J. W. Paslay
  • M. Pellecchia
  1. 1.Dept. Neuroscience ChemistryPfizer Global Research & DevelopmentGroton CTUSA

Bibliographic information

  • DOI https://doi.org/10.1007/978-3-642-01075-0
  • Copyright Information Springer-Verlag Berlin Heidelberg 2010
  • Publisher Name Springer, Berlin, Heidelberg
  • eBook Packages Chemistry and Materials Science
  • Print ISBN 978-3-642-01074-3
  • Online ISBN 978-3-642-01075-0
  • Series Print ISSN 1862-2461
  • Series Online ISSN 1862-247X
  • Buy this book on publisher's site
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