© 2009

Recent Advances in Transthyretin Evolution, Structure and Biological Functions

  • Samantha J. Richardson
  • Vivian Cody

Table of contents

  1. Front Matter
    Pages i-xiii
  2. Porntip Prapunpoj
    Pages 45-58
  3. Deborah M. Power, Isabel Morgado, João C. R. Cardoso
    Pages 59-75
  4. Giuseppe Zanotti, Ileana Ramazzina, Laura Cendron, Claudia Folli, Riccardo Percudani, Rodolfo Berni
    Pages 95-108
  5. A. Elisabeth Sauer-Eriksson, Anna Linusson, Erik Lundberg
    Pages 109-122
  6. Kiyoshi Yamauchi, Akinori Ishihara
    Pages 159-171
  7. Yukio Ando, Masaaki Nakamura, Mistuharu Ueda, Hirofumi Jono
    Pages 215-238
  8. Bo-Göran Ericzon, Erik Lundgren, Ole B. Suhr
    Pages 239-260
  9. Sadahiro Ito, Shuichiro Maeda
    Pages 261-280
  10. Julie A. Monk, Samantha J. Richardson
    Pages 297-310
  11. Carolina Estima Fleming, Ana Filipa Nunes, Márcia Almeida Liz, Mónica Mendes Sousa
    Pages 311-328

About this book


There is a strong interest in transthyretin (TTR) in connection with protein evolution, medical and clinical research. Thus, this is an exciting time for experts in TTR research to come together to write a monograph covering both the basic and the clinical research into TTR.

Transthyretin is a protein found in human blood and cerebrospinal fluid. It is directly involved in the transport of thyroid hormones, and indirectly in that of retinol. These hormones are essential for normal growth and development, particularly that of the brain. Spontaneous and inherited diseases affecting transthyretin result in amyloidosis. More than 80 point mutations in transthyretin lead to a variety of illnesses. Liver transplants are the most common treatment, although much research is also being carried out in drug therapies.

The evolution of transthyretin has been extensively investigated – from humans to bacteria, invertebrate animals and plants. The structure of the protein has not changed, but its function has changed significantly. This is a most exciting example for the study of the evolution of protein structure-function relationships.

This monograph will bring the reader up to date on the latest developments and discoveries.


bacteria biology growth hormone mutation neuropeptides physiology protein protein structure proteins synthesis thyroid hormone

Editors and affiliations

  • Samantha J. Richardson
    • 1
  • Vivian Cody
    • 2
  1. 1.School of Medical SciencesRMIT UniversityBundooraAustralia
  2. 2.Medical Research InstituteHauptman-WoodwardBuffaloUSA

Bibliographic information

Industry Sectors
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From the reviews: “Transthyretin (TTR) is a relatively abundant thyroid hormone carrier protein found in the blood of vertebrates. … The authors of the book Recent Advances in Transthyretin Evolution, Structure and Biological Functions have produced a comprehensive reference text that does much to reconcile the evolutionary biology, structure-function relationships and pathophysiology of this remarkable protein. … In summary, this … text will prove to be essential reading for both expert and non-expert researchers in the field of TTR biology.” (Rob Gasperini, Australian Biochemist, Vol. 41 (1), April, 2010)