© 2009

Toll-like Receptors: Roles in Infection and Neuropathology

  • Tammy Kielian

Part of the Current Topics in Microbiology and Immunology book series (CT MICROBIOLOGY, volume 336)

Table of contents

  1. Front Matter
    Pages i-xi
  2. Nilufer Esen, Tammy Kielian
    Pages 41-61
  3. Hyeon-Sook Suh, Celia F. Brosnan, Sunhee C. Lee
    Pages 63-81
  4. Bibhuti B. Mishra, Uma Mahesh Gundra, Judy M. Teale
    Pages 83-104
  5. Trevor Owens
    Pages 105-120
  6. Kristina A. Kigerl, Phillip G. Popovich
    Pages 121-136
  7. Gary E. Landreth, Erin G. Reed-Geaghan
    Pages 137-153
  8. Michael K. Racke, Paul D. Drew
    Pages 155-168
  9. Donghoon Kim, Soojin Lee, Sung Joong Lee
    Pages 169-186
  10. Back Matter
    Pages 187-191

About this book


Mammalian Toll-like receptors (TLRs) were first identified in 1997 based on their homology with Drosophila Toll, which mediates innate immunity in the fly. In recent years, the number of studies describing TLR expression and function in the nervous system has been increasing steadily and expanding beyond their traditional roles in infectious diseases to neurodegenerative disorders and injury. Interest in the field serves as the impetus for this volume in the Current Topics in Microbiology and Immunology series entitled "Toll-like receptors: Roles in Infection and Neuropathology". The first five chapters highlight more traditional roles for TLRs in infectious diseases of the CNS. The second half of the volume discusses recently emerging roles for TLRs in non-infectious neurodegenerative diseases and the challenges faced in these models with identifying endogenous ligands. Several conceptual theories are introduced in various chapters that deal with the dual nature of TLR engagement and whether these signals favor neuroprotective versus neurodegenerative outcomes. This volume should be informative for both experts as well as newcomers to the field of TLRs in the nervous system based on its coverage of basic TLR biology as well as specialization to discuss specific diseases of the nervous system where TLR function has been implicated. A must read for researchers interested in the dual role of these receptors in neuroinfection and neurodegeneration.


Alzheimer Alzheimer's disease CNS parasitic infections CNS viral infections Nervous System bacterial meningitis brain abscess endogenous ligand infections infectious disease multiple sclerosis peripheral nerve injury spinal cord injury

Editors and affiliations

  • Tammy Kielian
    • 1
  1. 1.Dept. Pathology & MicrobiologyUniversity of Nebraska Medical CenterOmahaU.S.A.

Bibliographic information

  • Book Title Toll-like Receptors: Roles in Infection and Neuropathology
  • Editors Tammy Kielian
  • Series Title Current Topics in Microbiology and Immunology
  • Series Abbreviated Title Current Topics Microbiology
  • DOI
  • Copyright Information Springer-Verlag Berlin Heidelberg 2009
  • Publisher Name Springer, Berlin, Heidelberg
  • eBook Packages Biomedical and Life Sciences Biomedical and Life Sciences (R0)
  • Hardcover ISBN 978-3-642-00548-0
  • Softcover ISBN 978-3-642-26911-0
  • eBook ISBN 978-3-642-00549-7
  • Series ISSN 0070-217X
  • Edition Number 1
  • Number of Pages XI, 191
  • Number of Illustrations 0 b/w illustrations, 8 illustrations in colour
  • Topics Neurosciences
  • Buy this book on publisher's site
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