© 2009

Bioengineering Research of Chronic Wounds

A Multidisciplinary Study Approach

  • Amit Gefen

Part of the Studies in Mechanobiology, Tissue Engineering and Biomaterials book series (SMTEB, volume 1)

Table of contents

  1. Front Matter
  2. Principles of ChronicWound Pathology, Pathomechanics and Healing Response

  3. Mathematical Modeling of Chronic Wounds and Wound Healing

  4. Computer Methods for Studying Biomechanical Conditions at Chronic Wound Sites: From Tissue to Cellular Scales

  5. Tissue-Engineered Constructs for Studying and Repairing Chronic Wounds

    1. M. W. Carlson, S. Dong, J. A. Garlick, C. Egles
      Pages 263-280
    2. M. D. Ming-Huei Cheng, S. Uriel, Eric M. Brey
      Pages 281-299
  6. Biochemical Markers for Early Identification and for Monitoring the Healing of Chronic Wounds

    1. Takashi Nagase, Hiromi Sanada, Gojiro Nakagami, Yunita Sari, Takeo Minematsu, Junko Sugama
      Pages 301-341
  7. Innovative Technologies and Devices in the Diagnosis and Treatment of Chronic Wounds

    1. Marco Romanelli, Valentina Dini
      Pages 363-380
    2. Michael Neidrauer, Elisabeth S. Papazoglou
      Pages 381-404
    3. Anshu B. Mathur
      Pages 405-424
    4. Levi Procter, Erin E. Falco, John P. Fisher, John S. Roth
      Pages 425-447

About this book


Pressure-related chronic wounds are an important health concern that affects millions of patients and accumulates billions in annual costs. These wounds may occur when soft tissues are mechanically compressed between bony prominences and a supporting surface. This book gives a complete and quantitative explanation of the mechanobiology which causes chronic wounds. The reviews give an overall picture on all length scales of the phenomenon, starting from musculoskeletal biomechanics to the modeling of soft tissues and their interaction with bones. At the microscopic levels, it thoroughly reviews experiments and modeling of cellular forces and molecular processes that occur during injury and healing, including the integrity of living cells subjected to sustained mechanical forces and deformations. The results allow a complete picture of the tolerance of human tissues to sustained loads, and an understanding of the risk for onset of chronic wounds. Hence, this book is also valuable for all professionals involved in the prevention and treatment of chronic wounds.


Biomaterial Monitor Proteom bioengineering biomechanics bone cells endothelium tissue tissue engineering

Editors and affiliations

  • Amit Gefen
    • 1
  1. 1.Fac. Engineering, Dept. Biomedical EngineeringTel Aviv UniversityRamat AvivIsrael

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