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Vaccines for Pandemic Influenza

  • Richard W. Compans
  • Walter A. Orenstein

Part of the Current Topics in Microbiology and Immunology book series (CT MICROBIOLOGY, volume 333)

Table of contents

  1. Front Matter
    Pages i-xviii
  2. Pandemic Influenza Overview

    1. Front Matter
      Pages 1-1
    2. Hui-Ling Yen, Robert G. Webster
      Pages 3-24
    3. Adrianus C. M. Boon, Richard J. Webby
      Pages 25-40
  3. Current Approaches for Human and Avian Vaccine Production

    1. Front Matter
      Pages 42-42
    2. Anthony E. Fiore, Carolyn B. Bridges, Nancy J. Cox
      Pages 43-82
    3. Grace L. Chen, Kanta Subbarao
      Pages 109-132
    4. Darrell R. Kapczynski, David E. Swayne
      Pages 133-152
  4. Novel Vaccine Approaches

    1. Front Matter
      Pages 164-164
    2. Taisuke Horimoto, Yoshihiro Kawaoka
      Pages 165-176
    3. Jüergen A. Richt, Adolfo García-Sastre
      Pages 177-195
    4. Jin Hyang Kim, Joshy Jacob
      Pages 197-210
    5. Matthew J. Sylte, David L. Suarez
      Pages 227-241
    6. Sarah A. Kopecky-Bromberg, Peter Palese
      Pages 243-267
    7. S. M. Kang, P. Pushko, R. A. Bright, G. Smith, R. W. Compans
      Pages 269-289
    8. Lauren J. DiMenna, Hildegund C. J. Ertl
      Pages 291-321
    9. Robert L. Atmar, Wendy A. Keitel
      Pages 323-344
  5. Novel Approaches for Vaccine Delivery

    1. Front Matter
      Pages 346-346
    2. Ioanna Skountzou, Sang-Moo Kang
      Pages 347-368
    3. Mark R. Prausnitz, John A. Mikszta, Michel Cormier, Alexander K. Andrianov
      Pages 369-393
  6. Vaccine Evaluation, Production and Distribution

    1. Front Matter
      Pages 396-396
    2. Ralph A. Tripp, S. Mark Tompkins
      Pages 397-412
    3. Suryaprakash Sambhara, Janet E. McElhaney
      Pages 413-429
    4. Wendy A. Keitel, Robert L. Atmar
      Pages 431-451
    5. Kathryn M. Edwards, Adam Sabow, Andrew Pasternak, John W. Boslego
      Pages 471-493
  7. Back Matter
    Pages 509-512

About this book

Introduction

Recent years have seen unprecedented outbreaks of avian influenza A viruses. In particular, highly pathogenic H5N1 viruses have not only resulted in widespread outbreaks in domestic poultry, but have been transmitted to humans resulting in numerous fatalities. The rapid expansion in their geographic distribution and the possibility that these viruses could acquire the ability to spread from person to person raise the risk that such a virus could cause a global pandemic with high morbidity and mortality. An effective influenza vaccine represents the best approach to prevent and control such an emerging pandemic. However, current influenza vaccines are directed at existing seasonal influenza viruses, which have limited antigenic relationships to the highly pathogenic H5N1 strains. Concerns about pandemic preparedness have greatly stimulated research activities to develop effective vaccines for pandemic influenza viruses, and to overcome the limitations inherent in current approaches to vaccine production and distribution. These limitations include the use of embryonated chicken eggs as the substrate for vaccine production; which is time-consuming and could involve potential biohazards in growth of new virus strains. Other limitations include the requirement that the current inactivated influenza vaccines be administered using needles and syringes, requiring trained personnel, which could be a bottleneck when attempting to vaccinate large populations in mass campaigns. In addition, the current inactivated vaccines which are delivered by injection elicit limited protective immunity in the upper respiratory tract where the infection process is initiated. Most of these limitations of the current vaccines are being addressed by research on novel approaches to vaccine development and delivery that are described in many of the chapters in this volume.

Keywords

Antigen DNA vaccines H5N1 viruses NS1 proteins Radiologieinformationssystem attenuated vaccines avian influenza influenza virus-like particles microneedle patches pandemic influenza protein seasonal influenza transcutaneous immunization vacci

Editors and affiliations

  • Richard W. Compans
    • 1
  • Walter A. Orenstein
    • 2
  1. 1.School of MedicineEmory UniversityAtlantaU.S.A.
  2. 2.School of MedicineEmory UniversityAtlantaU.S.A.

Bibliographic information

  • DOI https://doi.org/10.1007/978-3-540-92165-3
  • Copyright Information Springer Berlin Heidelberg 2009
  • Publisher Name Springer, Berlin, Heidelberg
  • eBook Packages Biomedical and Life Sciences
  • Print ISBN 978-3-540-92164-6
  • Online ISBN 978-3-540-92165-3
  • Series Print ISSN 0070-217X
  • Buy this book on publisher's site
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