Pharmacology and Therapeutics of Cough

  • Kian Fan Chung
  • John Widdicombe

Part of the Handbook of Experimental Pharmacology book series (HEP, volume 187)

Table of contents

  1. Front Matter
    Pages i-xii
  2. K. F. Chung, J. G. Widdicombe
    Pages 1-21
  3. S. Materazzi, R. Nassini, R. Gatti, M. Trevisani, P. Geppetti
    Pages 49-61
  4. S. B. Mazzone, B. J. Undem
    Pages 99-127
  5. M. A. McAlexander, M. J. Carr
    Pages 129-154
  6. D. Spina, I. McFadzean, F.K.R. Bertram, C. P. Page
    Pages 155-186
  7. C. -Y. Chen, J. P. Joad, J. Bric, A. C. Bonham
    Pages 187-201
  8. Back Matter
    Pages 369-375

About this book


The last decade or so has seen remarkable advances in our knowledge of cough. This applies especially to its basic mechanisms: the types of airway sensors, the phar- cological receptors on their membranes, the brainstem organization of the ‘cough centre’, and the involvement of the cerebral cortex in the sensations and the vol- tary control of cough. With the exception of the last of these, nearly all the studies have been on experimental animals rather than humans, for obvious reasons. One group of experimental studies has particular relevance to human patients, and that is the demonstration of the sensitization of cough pathways both in the periphery and in the brainstem. Similar sensitizations have been shown for patients with chronic cough or who have been exposed to pollutants, and it is reasonable to suppose that this is the basis of their cough and that the underlying mechanisms are generally similar in humans and other species. Important advances are also being made in clinical cough research. For the three main causes of clinical cough, asthma, post-nasal drip syndrome, and gast- oesophageal re?ux disease, we are beginning to understand the pathological processes involved. There remains a diagnostically obdurate group of idiopathic chronic coughers, but even for them approaches are being devised to clarify und- lying mechanisms and to establish diagnoses. Perhaps surprisingly, the ?eld in which there has been the least spectacular - vance is the therapy of cough.


Antitussives Atmen Cough sensors Respiratory Medicine cannabinoid opioid

Editors and affiliations

  • Kian Fan Chung
    • 1
  • John Widdicombe
    • 2
  1. 1.National Heart & Lung InstituteImperial CollegeLondonUK
  2. 2.University of LondonLondonUK

Bibliographic information

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