© 2008

Immunology, Phenotype First: How Mutations Have Established New Principles and Pathways in Immunology

  • Bruce Beutler

Part of the Current Topics in Microbiology and Immunology book series (CT MICROBIOLOGY, volume 321)

Table of contents

  1. Front Matter
    Pages i-xiii
  2. Immunodeficiency

  3. Self-Reactivity

    1. J. G. Ryan, D. L. Kastner
      Pages 169-184
    2. L. E. Matesic, N. G. Copeland, N. A. Jenkins
      Pages 185-200
    3. D. T. Umetsu, S. E. Umetsu, G. J. Freeman, R. H. DeKruyff
      Pages 201-215
  4. Back Matter
    Pages 217-220

About this book


This monograph deals with the impact of classical genetics in immunology, prov- ing examples of how large immunological questions were solved, and new fields opened to analysis through the study of phenotypes, either spontaneous or induced. As broad as biology has become, there are those who do not fully understand what the genetic approach is, and how it differs fundamentally from most of the methods available to natural scientists. They may hold the opinion that genetics has run its course since Mendel read his paper on peas in 1865. “Why bother with classical genetics,” they may ask. “Won’t all genes be knocked out soon anyway?” Or they are intimidated by genetics, with its heavy reliance on model organisms that seem so alien. “What has C. elegans to do with me?” the questioning might go. “It doesn’t even have lymphocytes. ” Such skeptics may be unaware that the mouse is fast becoming as tractable a model organism as the fly, and that humans may not be too far behind. So I would like to introduce the topic with a few words about the power of genetics, and why it has contributed so much to immunology, and to bi- ogy in general. Genetics, as the word is used here, is not merely the science of heredity, but much more than that. It is the science of exceptions: the science that takes note of heritable variation and seeks to explain it at the most fundamental level.


asthma autoimmune disease autoinflammatory syndrome autosomal recessive genodermatosis bronchial asthma cytomegalovirus infection flaviviruses immune recognition infections innate immunity itchy mice microbial drug resistance papillomaviruses;

Editors and affiliations

  • Bruce Beutler
    • 1
  1. 1.Department of ImmunologyScripps Research InstituteLa JollaUSA

Bibliographic information

  • Book Title Immunology, Phenotype First: How Mutations Have Established New Principles and Pathways in Immunology
  • Editors Bruce Beutler
  • Series Title Current Topics in Microbiology and Immunology
  • DOI
  • Copyright Information Springer Berlin Heidelberg 2008
  • Publisher Name Springer, Berlin, Heidelberg
  • eBook Packages Biomedical and Life Sciences Biomedical and Life Sciences (R0)
  • Hardcover ISBN 978-3-540-75202-8
  • Softcover ISBN 978-3-642-09445-3
  • eBook ISBN 978-3-540-75203-5
  • Series ISSN 0070-217X
  • Edition Number 1
  • Number of Pages XIII, 220
  • Number of Illustrations 0 b/w illustrations, 0 illustrations in colour
  • Topics Immunology
  • Buy this book on publisher's site
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