Modern Anesthetics

  • Jürgen Schüttler
  • Helmut Schwilden

Part of the Handbook of Experimental Pharmacology book series (HEP, volume 182)

Table of contents

  1. Front Matter
    Pages i-xv
  2. Molecular Mechanisms of Anesthetic Action

    1. B. W. Urban
      Pages 3-29
    2. A. Zeller, R. Jurd, S. Lambert, M. Arras, B. Drexler, C. Grashoff et al.
      Pages 31-51
    3. G. Akk, S. Mennerick, J. H. Steinbach
      Pages 53-84
    4. C. Nau
      Pages 85-92
    5. R. D. Sanders, D. Brian, M. Maze
      Pages 93-117
  3. Modern Inhalation Anesthetics

  4. Modern Intravenous Anesthetics

    1. C. Vanlersberghe, F. Camu
      Pages 227-252
    2. C. Vanlersberghe, F. Camu
      Pages 267-282
    3. F. S. Servin, V. Billard
      Pages 283-311
    4. B. Sinner, B. M. Graf
      Pages 313-333
    5. K. T. Olkkola, J. Ahonen
      Pages 335-360
  5. Pharmacokinetics-Pharmacodynamics Based Administration of Anesthetics

    1. P. Bischoff, G. Schneider, E. Kochs
      Pages 379-408
    2. S. L. Shafer, D. R. Stanski
      Pages 409-423
    3. H. Schwilden, J. Schüttler
      Pages 425-450
    4. J. -U. Meyer, G. Kullik, N. Wruck, K. Kück, J. Manigel
      Pages 451-470
  6. Back Matter
    Pages 489-498

About this book


Some important constraints of anesthesia must be taken into consideration when the pharmacological properties of modern anesthetics are discussed. The most imp- tant of these could be that the target effect be achieved preferably within seconds, at most within a few minutes. Similarly, offset of drug action should be achieved within minutes rather hours. The target effects, such as unconsciousness, are pot- tially life-threatening, as are the side effects of modern anesthetics, such as respi- tory and cardiovascular depression. Finally, the patient’s purposeful responses are not available to guide drug dosage, because, either the patient is unconscious, or more problematically, the patient is aware but unable to communicate pain because of neuromuscular blockade. These constraints were already recognised 35 years ago, when in 1972 Volume XXX entitled “Modern Inhalation Anesthetics” appeared in this Handbook Series. The present volume is meant as a follow up and extension of that volume. At the beginning of the 1970’s anesthesia was commonly delivered by inhalation, with only very few exceptions. The clinical understanding of that time considered anesthesia as a unique state achieved by any of the inhalation anesthetics, in- pendent of their specific molecular structure. “The very mechanism of anesthetic action at the biophase” was discussed within the theoretical framework of the “u- tary theory of narcosis”.


CNS Modern Anesthetics anesthesia depression drug kinetics neurotoxicity opioid pain pharmacodynamics pharmacokinetics research toxicity

Editors and affiliations

  • Jürgen Schüttler
    • 1
  • Helmut Schwilden
    • 1
  1. 1.Klinik fūr AnästhesiologieFriedrich-Alexander-Universität Erlangen-NürnbergErlangenGermany

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