Control of Biofilm Infections by Signal Manipulation

  • Editors
  • Naomi Balaban

Part of the Springer Series on Biofilms book series (BIOFILMS, volume 2)

Table of contents

  1. Front Matter
    Pages ii-xvi
  2. Naomi Balaban, Dacheng Ren, Michael Givskov, Thomas Bovbjerg Rasmussen
    Pages 1-11
  3. Michael Givskov, Thomas Bovbjerg Rasmussen, Dacheng Ren, Naomi Balaban
    Pages 13-38
  4. Robert J.C. McLean, Sandra A. Bryant, Dhiraj A. Vattem, Michael Givskov, Thomas Bovbjerg Rasmussen, Naomi Balaban
    Pages 39-50
  5. Dacheng Ren, Michael Givskov, Thomas Bovbjerg Rasmussen, Naomi Balaban
    Pages 51-77
  6. Naomi Balaban, Michael Givskov, Thomas Bovbjerg Rasmussen, Andrea Giacometti, Oscar Cirioni
    Pages 109-117
  7. Naomi Balaban, Michael Givskov, Thomas Bovbjerg Rasmussen
    Pages 119-129
  8. M. Dilani Senadheera, Fengxia Qi, Dennis Cvitkovitch
    Pages 131-140
  9. E. Peter Greenberg, Ehud Banin
    Pages 141-156
  10. Randall D. Wolcott
    Pages 157-170
  11. Back Matter
    Pages 171-175

About this book


The medical miracle of antibiotics is being eroded by the emergence and spread of bacterial drug resistance. This is compounded by the fact that bacterial biofilms are believed to be a common cause of persistent infections, when because growing in biofilms, bacteria are protected from the host’s immune response and from antibiotics. In addition, biofilms may spawn systemic infections by sloughing of planktonic bacteria, leading to dissemination, bacteremia, sepsis, and death. The number of patients affected by and dying from what can be considered as a "biofilm disease" is higher than heart disease and cancer combined, making medical biofilms the biggest single disease that the healthcare system is facing today.
This book describes the molecular mechanisms of cell-to-cell communication among bacterial cells in a biofilm, the development of antibiofilm inhibitors, like quorum-sensing inhibitors, and the use of biofilm inhibitors to prevent and treat bacterial infections in humans and other animals.


antibiotics bacteremia bacteria bacterial infection bacterial infections biofilm biofilm infection infection infections molecular mechanisms plankton signal manipulation

Bibliographic information

  • DOI
  • Copyright Information Springer-Verlag Berlin Heidelberg 2008
  • Publisher Name Springer, Berlin, Heidelberg
  • eBook Packages Biomedical and Life Sciences
  • Print ISBN 978-3-540-73852-7
  • Online ISBN 978-3-540-73853-4
  • Series Print ISSN 1863-9607
  • Buy this book on publisher's site
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