Table of contents
About this book
The understanding of the molecular mechanisms underlying the ageing process is essential to improve quality of life and ‘health span’ in the growing populations of the elderly.
Telomere shortening represents one of the basic aspects of ageing and telomere dysfunction could contribute to the accumulation of DNA damage during ageing. This book summarizes experimental evidence and clinical data indicating that telomere dysfunction influences human ageing, diseases and cancer. In addition, the book describes our current knowledge on checkpoints that limit cellular lifespan (senescence) and survival (apoptosis, crisis) in response to telomere dysfunction.
A special focus of the book is on adult stem cells. There is emerging evidence that adult stem cell ageing impairs organismal fitness and survival and contributes to cancer formation (cancer stem cells). The book summarizes basic mechanisms of adult stem cell ageing. Moreover, the authors describe evidence that telomere dysfunction impairs stem cell function by inducing cell intrinsic checkpoints as well as environmental alterations.
All of these subjects are of great interest for ageing researchers, physicians and students and should provide a rational basis for beginning to identify molecular targets for novel therapies that aim to improve quality of life during ageing.
Editors and affiliations
- Book Title Telomeres and Telomerase in Ageing, Disease, and Cancer
- Book Subtitle Molecular Mechanisms of Adult Stem Cell Ageing
K. Lenhard Rudolph
- DOI https://doi.org/10.1007/978-3-540-73709-4
- Copyright Information Springer-Verlag Berlin Heidelberg 2008
- Publisher Name Springer, Berlin, Heidelberg
- eBook Packages Biomedical and Life Sciences Biomedical and Life Sciences (R0)
- Hardcover ISBN 978-3-540-73708-7
- Softcover ISBN 978-3-642-09288-6
- eBook ISBN 978-3-540-73709-4
- Edition Number 1
- Number of Pages XIV, 330
- Number of Illustrations 39 b/w illustrations, 25 illustrations in colour
- Buy this book on publisher's site