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Inhibitory Regulation of Excitatory Neurotransmission

  • Editors
  • Mark G. Darlison

Part of the Results and Problems in Cell Differentiation book series (RESULTS, volume 44)

Table of contents

  1. Front Matter
    Pages I-XVI
  2. Matthew C. Walker, Alexey Semyanov
    Pages 29-48
  3. Matthias Schmidt
    Pages 49-67
  4. Andreas Draguhn, Nikolai Axmacher, Sergej Kolbaev
    Pages 69-85
  5. Jiang-Hong Ye
    Pages 123-143
  6. Thomas Knöpfel, Marylka Uusisaari
    Pages 163-175
  7. Karsten K. Madsen, Orla M. Larsson, Arne Schousboe
    Pages 201-221
  8. Back Matter
    Pages 243-248

About this book

Introduction

Within the central and peripheral nervous systems of animals, including man, inhibition is crucial to counterbalance excitatory neurotransmission, which is predominantly mediated by glutamate and its receptors. Although, particularly in brain, much of this inhibition is provided by classical post-synaptic GABAA receptors, many other proteins and mechanisms regulate excitation. These exist both to "fine tune" neurotransmission and to prevent overexcitation that could lead to conditions such as epilepsy and excitotoxicity, which can result in cell death. This book reviews aspects of GABAA receptor function, as well as the properties of a variety of other important inhibitory proteins, such as GABAC receptors, G-protein coupled receptors (specifically, GABAB receptors, metabotropic glutamate receptors and neuropeptide receptors), glycine receptors, GABA transporters and potassium channels. In addition, the consequences of mutations that disrupt the regulation of excitatory neurotransmission, and efforts to target the GABAergic system for therapeutic benefit, are discussed.

Keywords

G-Protein Coupled Receptor Glutamat Ion-Channel Receptor Nervous System Neuronal Inhibition Neurotransmission Regulation of Excitation metabolism neuropeptides proteins regulation

Bibliographic information

  • DOI https://doi.org/10.1007/978-3-540-72602-9
  • Copyright Information Springer-Verlag Berlin Heidelberg 2008
  • Publisher Name Springer, Berlin, Heidelberg
  • eBook Packages Biomedical and Life Sciences
  • Print ISBN 978-3-540-72601-2
  • Online ISBN 978-3-540-72602-9
  • Series Print ISSN 0080-1844
  • Buy this book on publisher's site
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