• J. A. E Spaan
  • Ruben Coronel
  • Jacques M. T. de Bakker
  • Antonio Zaza

Part of the Series in Biomedical Engineering book series (BIOMENG)

Table of contents

  1. Front Matter
    Pages I-VIII
  2. Jacques M. T. de Bakker, Antonio Zaza
    Pages 1-5
  3. Traian M. Anghel, Steven M. Pogwizd
    Pages 45-62
  4. Michael R. Rosen, Peter R. Brink, Ira S. Cohen, Richard B. Robinson
    Pages 63-78
  5. Gerard J. J. Boink, Jurgen Seppen, Jacques M. T. de Bakker, Hanno L. Tan
    Pages 79-93
  6. Teun P. de Boer, Toon A. B. van Veen, Marien J. C. Houtman, John A. Jansen, Shirley C. M. van Amersfoorth, Pieter A. Doevendans et al.
    Pages 94-104
  7. Ronald W. Joyner, Ronald Wilders, Mary B. Wagner
    Pages 105-120
  8. Ronald Wilders
    Pages 121-148
  9. Yuichi Tomita, Shinji Makino, Daihiko Hakuno, Naoichiro Hattan, Kensuke Kimura, Shunichiro Miyoshi et al.
    Pages 149-167
  10. Arjang Ruhparwar, Fikret Er, Ulrich Martin, Kristin Radke, Ina Gruh, Michael Niehaus et al.
    Pages 168-177
  11. Back Matter
    Pages 179-182

About this book


The development of a bio-engineered pacemaker is of substantial clinical and also scientific interest because it promises to overcome several limitations of electronic pacemakers. Moreover it may answer the longstanding question of whether the complex structure of the sinus node is indeed a prerequisite for reliable pacemaking, or simpler structures might work as well.

This book gives an overview of the current state-of-the-art of creating a bio-engineered pacemaker. It shows the approaches to develop of genetic and cell-based engineering methods suitable to implement them with safety and stability. It also illuminates the problems that need to be solved before bio-pacemaking can be considered for clinical use.


Cardiac Signals Electrocardiogram IFMBE cells computer

Editors and affiliations

  • J. A. E Spaan
    • 1
  • Ruben Coronel
    • 2
  • Jacques M. T. de Bakker
    • 3
    • 4
    • 5
  • Antonio Zaza
    • 6
  1. 1.Academic Medical CenterAmsterdamThe Netherlands
  2. 2.Department of Experimental CardiologyAcademic Medical CenterAmsterdamThe Netherlands
  3. 3.Department of Experimental Cardiology Center for Heart Failure ResearchAcademic Medical CenterAmsterdam
  4. 4.The Heart Lung CenterUniversity Medical CenterUtrecht
  5. 5.The Interuniversity CardiologyInstitute of the NetherlandsUtrechtThe Netherlands
  6. 6.Dipartimento di Biotecnologie e BioscienzeUniversità di Milano-BicoccaMilanoItaly

Bibliographic information

  • DOI
  • Copyright Information Springer-Verlag Berlin Heidelberg 2007
  • Publisher Name Springer, Berlin, Heidelberg
  • eBook Packages Engineering
  • Print ISBN 978-3-540-72109-3
  • Online ISBN 978-3-540-72110-9
  • Series Print ISSN 1864-5763
  • Buy this book on publisher's site
Industry Sectors
Materials & Steel
Health & Hospitals
Consumer Packaged Goods