Vitiligo

1. Defining the Disease

   1. Natural History and Prognosis

      • Davinder Parsad

      Pages 139-142

   2. Defining the Disease: Editor's Synthesis

      • Alain Taïeb, Mauro Picardo

      Pages 143-146

2. Understanding the Disease

   1. Front Matter

      Pages 148-148

      PDF

   2. Pathophysiology Overview

      • Mauro Picardo, Alain Taïeb

      Pages 149-152

   3. Editor’s Synthesis

      • Mauro Picardo, Alain Taïeb

      Pages 311-315

   4. Generalized Vitiligo

      1. Genetics

         • Richard Spritz

         Pages 155-163

      2. Environmental Factors

         • Yvon Gauthier, Laila Benzekri, Raymond E. Boissy

         Pages 166-180

      3. In Vivo Data

         • Marco Ardigò, Yvon Gauthier, Francesca Muzio, Mauro Picardo, Valeria Brazzelli

         Pages 182-203

      4. Animal Models

         • Gisela F. Erf

         Pages 205-218

      5. In Vitro Approaches

         • Muriel Cario-André, Maria Lucia Dell'Anna

         Pages 219-230

      6. Oxidative Stress

         • Mauro Picardo, Maria Lucia Dell'Anna

         Pages 231-237

      7. Immune/Inflammatory Aspects

         • Alain Taïeb, Anna Peroni, Giampiero Girolomoni, E. Helen Kemp, Anthony P. Weetman, David J. Gawkrodger et al.

         Pages 239-267

      8. Cytokines and Growth Factors

         • Genji Imokawa, Silvia Moretti, G Imokawa, S Moretti, M Picardo, A Taïeb et al.

         Pages 269-282

      9. Proopiomelanocortin and Related Hormones

         • Markus Böhm

         Pages 283-290

      10. Other Hypotheses

          • Mauro Picardo

          Pages 291-293

   5. Segmental Vitiligo: A Model to Understand Vitiligo?

      1. Particular Clinical Characteristics of Segmental Vitiligo

         • Seung-Kyung Hann

         Pages 296-298

      2. The Concept of Mosaicism Applied to SV

         • Alain Taïeb

         Pages 298-302

      3. The Neurogenic Hypothesis in Segmental Vitiligo

         • Yvon Gauthier, Laila Benzekri

         Pages 302-305

      4. Segmental Vitiligo: A Model for Understanding the Recapitulation of Repigmentation

         • Hsin-Su Yu, Cheng-Che Eric Lan, Ching-Shuang Wu

         Pages 306-310

3. Therapy

   1. Front Matter

      Pages 318-318

      PDF

Vitiligo has been, until recently, a rather neglected area in dermatology and medicine. Patients complain about this situation, which has offered avenues to quacks, and has led to the near orphan status of the disease. The apparently, simple and poorly symptomatic presentation of the disease has been a strong disadvantage to its study, as compared to other common chronic skin disorders such as psoriasis and atopic dermatitis. Vitiligo is still considered by doctors as a non disease, a simple aesthetic problem. A good skin-based angle of attack is also lacking because generalized vi- ligo is clearly epitomizing the view of skin diseases as simple targets of a systemic unknown dysregulation (diathesis), re? ecting the Hippocratic doctrine. This view has mostly restricted vitiligo to the manifestation of an auto-immune diathesis in the past 30 years. Thus, skin events, which are easily detected using skin biospies in most other situations, have not been precisely recorded, with the argument that a clinical diagnosis was suf? cient for the management (or most commonly absence of mana- ment) of the patient. This book is an international effort to summarize the information gathered about this disorder at the clinical, pathophysiological and therapeutic levels. Its primary aim is to bridge current knowledge at the clinical and investigative level, to point to the many unsolved issues, and to delineate future priorities for research.

• Vivo
• diagnosis
• evidence based medicine
• generalized vitiligo
• inflammatory aspects
• melanocyte
• melanocyte transplantation
• phototherapy

• Istituto Dermatologico San Gallicano, Roma, Italy

  Mauro Picardo

• Service de Dermatologie De Dermatologie Pédiatrique, Centre de référence des maladies rares de la Peau Hôpital Saint-André, Bordeaux, France

  Alain Taïeb

Policies and ethics