Nicotine Psychopharmacology

  • Jack E. Henningfield
  • Edythe D. London
  • Sakire Pogun

Part of the Handbook of Experimental Pharmacology book series (HEP, volume 192)

Table of contents

  1. Front Matter
    Pages i-xiv
  2. Nicotine and Tobacco Consumption: Measurement and Trends

    1. S. Katharine Hammond
      Pages 3-28
    2. Neal L. Benowitz, Janne Hukkanen, Peyton Jacob III
      Pages 29-60
    3. Mirjana V. Djordjevic, Kelly A. Doran
      Pages 61-82
  3. Nicotine Pharmacology and Mechanisms of Action

    1. Allan C. Collins, Outi Salminen, Michael J. Marks, Paul Whiteaker, Sharon R. Grady
      Pages 85-112
    2. Allen Azizian, John Monterosso, Joseph O'Neill, Edythe D. London
      Pages 113-143
    3. Anil Sharma, Arthur L. Brody
      Pages 145-171
    4. Jacques Barik, Susan Wonnacott
      Pages 173-207
    5. Jill C. Mwenifumbo, Rachel F. Tyndale
      Pages 235-259
    6. Sakire Pogun, Gorkem Yararbas
      Pages 261-291
  4. Nicotine Psychopharmacology

    1. Janice W. Smith, Ian P. Stolerman
      Pages 295-333
    2. David H. Malin, Pilar Goyarzu
      Pages 401-434
  5. Approaches, Challenges, and Experience in Assessing Free Nicotine

    1. David L. Ashley, James F. Pankow, Ameer D. Tavakoli, Clifford H. Watson
      Pages 437-456
    2. Geoffrey Ferris Wayne, Carrie M. Carpenter
      Pages 457-485
    3. Reginald V. Fant, August R. Buchhalter, Albert C. Buchman, Jack E. Henningfield
      Pages 487-510
    4. Jack E. Henningfield, Mitch Zeller
      Pages 511-534
  6. Back Matter
    Pages 535-544

About this book


The fact that tobacco ingestion can affect how people feel and think has been known for millennia, placing the plant among those used spiritually, honori?cally, and habitually (Corti 1931; Wilbert 1987). However, the conclusion that nicotine - counted for many of these psychopharmacological effects did not emerge until the nineteenth century (Langley 1905). This was elegantly described by Lewin in 1931 as follows: “The decisive factor in the effects of tobacco, desired or undesired, is nicotine. . . ”(Lewin 1998). The use of nicotine as a pharmacological probe to und- stand physiological functioning at the dawn of the twentieth century was a landmark in the birth of modern neuropharmacology (Limbird 2004; Halliwell 2007), and led the pioneering researcher John Langley to conclude that there must exist some “- ceptive substance” to explain the diverse actions of various substances, including nicotine, when applied to muscle tissue (Langley 1905). Research on tobacco and nicotine progressed throughout the twentieth century, but much of this was from a general pharmacological and toxicological rather than a psychopharmacological perspective (Larson et al. 1961). There was some attention to the effects related to addiction, such as euphoria (Johnston 1941), tolerance (Lewin 1931), and withdrawal (Finnegan et al. 1945), but outside of research supported by the tobacco industry, addiction and psychopharmacology were not major foci for research (Slade et al. 1995; Hurt and Robertson 1998; Henning?eld et al. 2006; Henning?eld and Hartel 1999; Larson et al. 1961).


Imaging Molecular Nicotine Psychopharmacology Receptor Syndrom genetics

Editors and affiliations

  • Jack E. Henningfield
    • 1
  • Edythe D. London
    • 2
  • Sakire Pogun
    • 3
  1. 1.Pinney AssociatesBethesdaUSA
  2. 2.UCLA Semel Institute for Neuroscience and Human BehaviorLos AngelesUSA
  3. 3.Center for Brain Research, BornovaEge UniversityIzmirTurkey

Bibliographic information

  • DOI
  • Copyright Information Springer Berlin Heidelberg 2009
  • Publisher Name Springer, Berlin, Heidelberg
  • eBook Packages Biomedical and Life Sciences
  • Print ISBN 978-3-540-69246-1
  • Online ISBN 978-3-540-69248-5
  • Series Print ISSN 0171-2004
  • Buy this book on publisher's site
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