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© 2007

Tissue-Specific Estrogen Action

Novel Mechanisms, Novel Ligands, Novel Therapies

  • Editors
  • K. S. Korach
  • T. Wintermantel
Conference proceedings

Part of the Ernst Schering Foundation Symposium Proceedings book series (SCHERING FOUND, volume 2006/1)

Table of contents

  1. Front Matter
    Pages i-xv
  2. S. A. Johnsen, S. Kangaspeska, G. Reid, F. Gannon
    Pages 1-12
  3. T. M. Wintermantel, J. Elzer, A. E. Herbison, K.-H. Fritzemeier, G. Schütz
    Pages 25-44
  4. E. R. Simpson, M. E. Jones
    Pages 45-68
  5. J.- F. Arnal, H. Laurell, F. Lenfant, V. Douin-Echinard, L. Brouchet, P. Gourdy
    Pages 69-86
  6. P. A. Arias-Loza, V. Jazbutyte, K.-H. Fritzemeier, C. Hegele-Hartung, L. Neyses, G. Ertl et al.
    Pages 87-106
  7. S. J. McPherson, S. J. Ellem, V. Patchev, K. H. Fritzemeier, G. P. Risbridger
    Pages 131-148
  8. Back Matter
    Pages 183-183

About these proceedings

Introduction

Nuclear hormone receptors are not only important drug targets, but have also been the focus of decades of active and highly insightful research. Ten years ago, a review on nuclear receptors was entitled “The Second Decade” and a special issue of Molecular Endocrinology in 2005 dealt with the results of these research efforts. The consensus from nuclear receptor research was of course that the signaling pathways mediated by these receptors warrant further research, even though in principle they appeared to represent the most immediate, seemingly simple signaling pathway from hormone (ligand) binding to gene expression changes. In nuclear receptor molecular biology, estrogen receptor research has additional unique facets: since the discovery of ethinyl estradiol by Inhoffen and Hohlweg in the laboratories of Schering AG in the 1930s—and therefore several decades longer than nuclear receptor - searchitself—estrogenreceptorshavebeentargetsofwidelyused,orally administered drugs. Thus, accumulating clinical experience on estrogen action in vivo helps to support the progress in molecular biological research.

Keywords

Cardiovascular Biology Endocrinology Molecular Medicine Pharmacology Steroids cell biology cells endothelium estrogen action estrogen receptor receptor signaling tissue

Bibliographic information

  • Book Title Tissue-Specific Estrogen Action
  • Book Subtitle Novel Mechanisms, Novel Ligands, Novel Therapies
  • Editors Kenneth S. Korach
    Tim Wintermantel
  • Series Title Ernst Schering Foundation Symposium Proceedings
  • DOI https://doi.org/10.1007/978-3-540-49548-2
  • Copyright Information Springer-Verlag Berlin Heidelberg 2007
  • Publisher Name Springer, Berlin, Heidelberg
  • eBook Packages Medicine Medicine (R0)
  • Hardcover ISBN 978-3-540-49547-5
  • Softcover ISBN 978-3-642-42103-7
  • eBook ISBN 978-3-540-49548-2
  • Series ISSN 0947-6075
  • Edition Number 1
  • Number of Pages XV, 181
  • Number of Illustrations 0 b/w illustrations, 0 illustrations in colour
  • Topics Human Physiology
    Endocrinology
    Gynecology
    Medical Biochemistry
    Molecular Medicine
    Pharmacology/Toxicology
  • Buy this book on publisher's site
Industry Sectors
Biomedicine
Biotechnology
Health & Hospitals
Pharma

Reviews

From the reviews:

"This summation of a symposium discusses some of the new research developments and estrogen-receptor based therapies that are being tested in the laboratory and in current use. … It is written for researchers, physician scientists, and those interested in estrogen receptor interactions at a molecular level. Hopefully, it can also stimulate interest in and future research by graduate students or clinical/basic researchers." (Amber R. Cooper, Doody’s Review Service, January 2008)