© 2008

Late Effects of Cancer Treatment on Normal Tissues

  • Philip Rubin
  • Louis S. Constine
  • Lawrence B. Marks
  • Paul Okunieff

Part of the Medical Radiology book series (MEDRAD)

Table of contents

  1. Front Matter
    Pages I-XXII
  2. Melissa M. Hudson, Wendy Landier, Smita Bhatia, Kevin C. Oeffinger, Charles Sklar, Anna Meadows et al.
    Pages 1-9
  3. C. Norman Coleman
    Pages 11-17
  4. Luis Felipe L. -G. Fajardo
    Pages 19-22
  5. Richard P. Hill, Mohammed A. Khan, Aimee R. Langan, Ivan W. T. Yeung, Jake Van Dyk
    Pages 31-36
  6. Zafer Kocak, Lalitha Shankar, Daniel C. Sullivan, Lawrence B. Marks
    Pages 37-45
  7. M. Jacob Adams, Robert G. Prosnitz, Louis S. Constine, Lawrence B. Marks, Steven E. Lipshultz
    Pages 47-59
  8. Mitchell Steven Anscher, Zeljko Vujaskovic
    Pages 61-67
  9. Eric P. Cohen, Melissa M. Joines, John E. Moulder
    Pages 69-76
  10. Eric J. Hall, David J. Brenner
    Pages 77-81
  11. Moyed Miften, Olivier Gayou, David S. Parda, Robert Prosnitz, Lawrence B. Marks
    Pages 83-89
  12. Gary R. Morrow, Joseph A. Roscoe, Maralyn E. Kaufman, Christopher Bole, Colmar Figueroa-Moseley, Maarten Hofman et al.
    Pages 91-98
  13. Philip Rubin
    Pages 99-107
  14. Noreen M. Aziz
    Pages 109-130
  15. Back Matter
    Pages 131-143

About this book


The search for the most favorable therapeutic ratio – at which ablation of cancer is achieved while normal tissues are conserved – has been modern radiation oncology’s equivalent of the quest for the Holy Grail. Our awareness of the late effects of radiation grew during the past century as new modalities were introduced. Heightened normal tissue reactions accompanied the higher rates of cancer ablation achieved by escalation of radiation doses, accelerated fractionated radiotherapy, and aggressive concurrent chemotherapy and radiation regimens. This volume is based on the LENT V NCI-sponsored meeting held in May 2004 and the CURED I conference held in 2006. Written by experts in the field, it addresses a number of critical topics relating to late effects, such as mechanisms of injury, the role of screening, options for interventions, second malignancies, and prevention. It is hoped that it will assist the reader in understanding how to prevent and treat the long-term side-effects of irradiation.


Fatigue TNM TNM staging system cancer cancer treatment cell imaging inflammation pathology physiology prevention radiation radiation damage radiotherapy screening

Editors and affiliations

  • Philip Rubin
    • 1
  • Louis S. Constine
    • 2
  • Lawrence B. Marks
    • 3
  • Paul Okunieff
    • 1
  1. 1.Department of Radiation OncologyUniversity of Rochester School of Medicine and DentistryRochesterUSA
  2. 2.Department of Radiation Oncology, Departments of Radiation Oncology and PediatricsUniversity of Rochester School of Medicine and DentistryRochesterUSA
  3. 3.Department of Radiation OncologyDuke University Medical CenterDurhamUSA

Bibliographic information

  • Book Title Late Effects of Cancer Treatment on Normal Tissues
  • Editors Philip Rubin
    L.S. Constine
    Lawrence B. Marks
    Paul Okunieff
  • Series Title Medical Radiology
  • DOI
  • Copyright Information Springer-Verlag Berlin Heidelberg 2008
  • Publisher Name Springer, Berlin, Heidelberg
  • eBook Packages Medicine Medicine (R0)
  • Hardcover ISBN 978-3-540-49069-2
  • Softcover ISBN 978-3-642-08032-6
  • eBook ISBN 978-3-540-49070-8
  • Series ISSN 0942-5373
  • Edition Number 1
  • Number of Pages XXII, 140
  • Number of Illustrations 38 b/w illustrations, 30 illustrations in colour
  • Topics Imaging / Radiology
    Surgical Oncology
    Internal Medicine
  • Buy this book on publisher's site
Industry Sectors
Health & Hospitals


From the reviews:

"This book provides a basic science understanding of the processes behind the side effects of radiation. … is appropriate for residents, clinicians, radiobiologists, and medical physicists as it addresses the fundamentals necessary for a firm understanding of radiation sequelae. … The color pictures, graphs, diagrams, and tables beautifully illustrate the main concepts of each chapter. … Chapters outline the guidelines and models for researchers and clinicians … . should be in the library of every radiation oncology department." (Ann Pittier, Doody’s Review Service, August, 2008)