The Molecular Genetics of Aging

  • Siegfried Hekimi

Part of the Results and Problems in Cell Differentiation book series (RESULTS, volume 29)

Table of contents

  1. Front Matter
    Pages I-XV
  2. Thomas Perls, Dellara F. Terry, Margery Silver, Maureen Shea, Jennifer Bowen, Erin Joyce et al.
    Pages 1-20
  3. Rajindar S. Sohal, Robin J. Mockett, William C. Orr
    Pages 45-66
  4. Stephen L. Helfand, Blanka Rogina
    Pages 67-80
  5. Laura A. Herndon, Monica Driscoll
    Pages 113-129
  6. Gordon J. Lithgow
    Pages 131-148
  7. Naoaki Ishii, Philip S. Hartman
    Pages 149-164
  8. Martijn E. T. Dollé, Heidi Giese, Harry van Steeg, Jan Vijg
    Pages 165-180
  9. Back Matter
    Pages 237-240

About this book


This book offers insight into the current state of investigation into the genetic basis of aging and longevity. It has been written by scientists at the forefront of their field, thus providing a cross-section of current research. The topics covered include work with model organisms such as yeast, fruit flies, the nematode C. elegans, and mice. The most recent findings on the genetics of centenarians and the link between reproduction and life span in humans are also treated. The level of investigation ranges from the identification of life span determining genes by classic epidemiological methods to direct manipulation of rates of aging by molecular biological techniques in the most experimentally tractable systems. Further, it critically examines the significance of some lines of investigation and highlights those theories which may be most capable of providing a synthetic view of current data in the field of aging.


Telomere Termination Vivo age aging cancer enzymes gene expression genes genetics influence lifespan molecular mechanisms morbidity regulation

Editors and affiliations

  • Siegfried Hekimi
    • 1
  1. 1.Department of BiologyMcGill UniversityMontréalCanada

Bibliographic information

  • DOI
  • Copyright Information Springer-Verlag Berlin Heidelberg 2000
  • Publisher Name Springer, Berlin, Heidelberg
  • eBook Packages Springer Book Archive
  • Print ISBN 978-3-642-53686-1
  • Online ISBN 978-3-540-48003-7
  • Series Print ISSN 0080-1844
  • Series Online ISSN 1861-0412
  • Buy this book on publisher's site
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