© 2007

Conditional Mutagenesis: An Approach to Disease Models

  • Robert Feil
  • Daniel Metzger

Part of the Handbook of Experimental Pharmacology book series (HEP, volume 178)

Table of contents

  1. Front Matter
    Pages I-XI
  2. Tools for Conditional Mutagenesis

    1. Front Matter
      Pages 1-1
    2. V. Brault, V. Besson, L. Magnol, A. Duchon, Y. Hérault
      Pages 29-48
    3. R. Sprengel, M. T. Hasan
      Pages 49-72
    4. W. Weber, M. Fussenegger
      Pages 73-105
    5. J. S. Drape, A. Nagy
      Pages 107-128
    6. A. Abuin, G. M. Hansen, B. Zambrowicz
      Pages 129-147
    7. R. Kühn, S. Streif, W. Wurst
      Pages 149-176
    8. P. Osten, V. Grinevich, A. Cetin
      Pages 177-202
  3. Examples of Conditional Disease Models

About this book


Leading experts provide timely and comprehensive information on methods for conditional mutagenesis in the mouse (part 1) and their application to model human physiology and pathophysiology (part 2). It illustrates how sophisticated genetic manipulations of the mouse genome are employed to model human diseases and to identify underlying molecular mechanisms. Finally the book considers the development of new drugs to treat them.


Chromosom conditional mutagenesis cre recombinase drug development gene knockout genes molecular mechanisms mouse models of human diseases pathophysiology physiology

Editors and affiliations

  • Robert Feil
    • 1
  • Daniel Metzger
    • 2
  1. 1.Interfakultäres Institut für Biochemie (IFIB) Signaltransduktion — transgene ModelleUniversität TübingenTübingenGermany
  2. 2.Institut de Génétique et de Biologie Moléculaire et Cellulaire (IGBMC)IllkirchFrance

Bibliographic information

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From the reviews:

"This is a comprehensive overview of generating mouse models with conditional modification of genes to study the effects of gene dysfunction in the development of human diseases. … The authors target general scientific researchers … . This book will be very informative for any scientists and students interested in using or generating genetically modified mouse models in biomedical research. … an excellent reference on the most recent progress in generating conditional knockout mice." (Grace L Guo, Doody’s Review Service, July, 2008)