Conditional Mutagenesis: An Approach to Disease Models

  • Robert Feil
  • Daniel Metzger

Part of the Handbook of Experimental Pharmacology book series (HEP, volume 178)

Table of contents

  1. Front Matter
    Pages I-XI
  2. Tools for Conditional Mutagenesis

    1. Front Matter
      Pages 1-1
    2. V. Brault, V. Besson, L. Magnol, A. Duchon, Y. Hérault
      Pages 29-48
    3. R. Sprengel, M. T. Hasan
      Pages 49-72
    4. W. Weber, M. Fussenegger
      Pages 73-105
    5. J. S. Drape, A. Nagy
      Pages 107-128
    6. A. Abuin, G. M. Hansen, B. Zambrowicz
      Pages 129-147
    7. R. Kühn, S. Streif, W. Wurst
      Pages 149-176
    8. P. Osten, V. Grinevich, A. Cetin
      Pages 177-202
  3. Examples of Conditional Disease Models

    1. Front Matter
      Pages 233-233
    2. D. Vignjevic, S. Fre, D. Louvard, S. Robine
      Pages 263-287
    3. K. Baumgärtel, C. Fernández, T. Johansson, I. M. Mansuy
      Pages 315-345
    4. K. L. Stark, C. Gross, J. Richardson-Jones, X. Zhuang, R. Hen
      Pages 347-363
    5. A. Nguyen Din Cat, Y. Sainte-Marie, F. Jaisser
      Pages 377-405
    6. S. Moosmang, T. Kleppisch, J. Wegener, A. Welling, F. Hofmann
      Pages 469-490
  4. Back Matter
    Pages 525-529

About this book


Leading experts provide timely and comprehensive information on methods for conditional mutagenesis in the mouse (part 1) and their application to model human physiology and pathophysiology (part 2). It illustrates how sophisticated genetic manipulations of the mouse genome are employed to model human diseases and to identify underlying molecular mechanisms. Finally the book considers the development of new drugs to treat them.


Chromosom conditional mutagenesis cre recombinase drug development gene knockout genes molecular mechanisms mouse models of human diseases pathophysiology physiology

Editors and affiliations

  • Robert Feil
    • 1
  • Daniel Metzger
    • 2
  1. 1.Interfakultäres Institut für Biochemie (IFIB) Signaltransduktion — transgene ModelleUniversität TübingenTübingenGermany
  2. 2.Institut de Génétique et de Biologie Moléculaire et Cellulaire (IGBMC)IllkirchFrance

Bibliographic information

  • DOI
  • Copyright Information Springer-Verlag Berlin Heidelberg 2007
  • Publisher Name Springer, Berlin, Heidelberg
  • eBook Packages Biomedical and Life Sciences
  • Print ISBN 978-3-540-35108-5
  • Online ISBN 978-3-540-35109-2
  • Series Print ISSN 0171-2004
  • Buy this book on publisher's site
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