© 2007

Acute Promyelocytic Leukemia

Molecular Genetics, Mouse Models and Targeted Therapy

  • Pier Paolo Pandolfi
  • Peter K. Vogt

Part of the Current Topics in Microbiology and Immunology book series (CT MICROBIOLOGY, volume 313)

Table of contents

  1. Front Matter
    Pages I-VII
  2. M. J. McConnell, J. D. Licht
    Pages 31-48
  3. J. -S. Seeler, O. Bischof, K. Nacerddine, A. Dejean
    Pages 49-71
  4. C. Nervi, F. Fazi, A. Rosa, A. Fatica, I. Bozzoni
    Pages 73-84
  5. P. P. Scaglioni, P. P. Pandolfi
    Pages 85-100
  6. P. Fenaux, Z. Z. Wang, L. Degos
    Pages 101-128
  7. Z. Chen, W. -L. Zhao, Z. -X. Shen, J. -M. Li, S. -J. Chen, J. Zhu et al.
    Pages 129-144
  8. K. Petrie, N. Prodromou, A. Zelent
    Pages 157-203
  9. P. G. Maslak, J. G. Jurcic, D. A. Scheinberg
    Pages 205-219
  10. Back Matter
    Pages 271-276

About this book


Over the past 10 years, work on acute promyelocytic leukemia (APL) has become the paradigm of translational research that began with the discovery of a recurrent chromosomal translocation, followed by the identification of the genes and proteins involved, finding their molecular functions in transcriptional control, establishing mouse models and culminating in the development  of targeted therapy.


All-trans retinoic acid (ATRA) Chromosom Small ubiquitin-like modifier (SUMO) clinical trial genes genetics leukemia microRNA molecular genetics peptides protein proteins targeted therapy transcription translation

Editors and affiliations

  • Pier Paolo Pandolfi
    • 1
  • Peter K. Vogt
    • 2
  1. 1.Memorial Sloan-Kettering Cancer CenterSloan-Kettering-InstituteNew YorkUSA
  2. 2.The Scripps Research InstituteLa JollaUSA

Bibliographic information

  • Book Title Acute Promyelocytic Leukemia
  • Book Subtitle Molecular Genetics, Mouse Models and Targeted Therapy
  • Editors Pier Paolo Pandolfi
    Peter K. Vogt
  • Series Title Current Topics in Microbiology and Immunology
  • DOI
  • Copyright Information Springer-Verlag Berlin Heidelberg 2007
  • Publisher Name Springer, Berlin, Heidelberg
  • eBook Packages Biomedical and Life Sciences Biomedical and Life Sciences (R0)
  • Hardcover ISBN 978-3-540-34592-3
  • Softcover ISBN 978-3-642-03611-8
  • eBook ISBN 978-3-540-34594-7
  • Series ISSN 0070-217X
  • Edition Number 1
  • Number of Pages VIII, 274
  • Number of Illustrations 7 b/w illustrations, 9 illustrations in colour
  • Topics Cancer Research
  • Buy this book on publisher's site
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