© 2007

Technetium-99m Pharmaceuticals

Preparation and Quality Control in Nuclear Medicine

  • Ilse Zolle
  • Advances made in forty years of radiopharmaceutical development based on Technetium

  • Good manufacturing practice (GMP) and the official quality standards stated for radiopharmaceuticals are part of the quality assurance


Table of contents

  1. Front Matter
    Pages I-XX
  2. Part I

    1. Front Matter
      Pages 1-1
    2. I. Zolle
      Pages 3-5
    3. U. Mazzi, R. Schibli, H. -J. Pietzsch, J. -U. Künstler, H. Spies
      Pages 7-58
    4. T. Bringhammar, I. Zolle
      Pages 67-75
    5. J. Mallol, I. Zolle
      Pages 95-98
    6. C Decristoforo, I Zolle, F. Rakiás, J Imre, Gy. Jánoki, S. R. Hesslewood
      Pages 123-150
  3. Part II

    1. Front Matter
      Pages 171-171
    2. I. Zolle, P. O. Bremer, Gy. Jánoki
      Pages 173-337
  4. Back Matter
    Pages 339-345

About this book


This textbook gives an account of the accomplishments related to the development of 99mTc-radiopharmaceuticals and their application in diagnostic nuclear medicine. Since radioactive drug development is a multi-disciplinary task, experts working in nuclear medicine and research institutions have contributed valuable information concerning the preparation with sterile kits, methods of quality control, and the use of 99mTc-radiopharmaceuticals in patients. In addition, the legal aspects governing production and clinical application are also considered. Section 1 contains basic principles and methods used for analysis. Special emphasis is given to the analytical methods verifying pharmaceutical quality. Section 2 contains monographs of 99mTc-radiopharmaceuticals used in nuclear medicine. Each monograph includes information on the chemistry, formulation, commercial products and trade names, factors affection in-vivo performance, clinical information on pharmacokinetics, as well as details concerning the clinical application and the radiation dose to patients. This book can serve for daily practice in nuclear medicine, serving as a reference source as well as a teaching tool.


Quality control Radiation dose Radiopharmaceutical Technetium positron emission tomography

Editors and affiliations

  • Ilse Zolle
    • 1
  1. 1.Department of Medicinal/Pharmaceutical ChemistryUniversity of ViennaViennaAustria

Bibliographic information

  • Book Title Technetium-99m Pharmaceuticals
  • Book Subtitle Preparation and Quality Control in Nuclear Medicine
  • Editors Ilse Zolle
  • DOI
  • Copyright Information Springer Berlin Heidelberg 2007
  • Publisher Name Springer, Berlin, Heidelberg
  • eBook Packages Medicine Medicine (R0)
  • Hardcover ISBN 978-3-540-33989-2
  • Softcover ISBN 978-3-642-07050-1
  • eBook ISBN 978-3-540-33990-8
  • Edition Number 1
  • Number of Pages XX, 345
  • Number of Illustrations 65 b/w illustrations, 1 illustrations in colour
  • Topics Imaging / Radiology
    Nuclear Medicine
  • Buy this book on publisher's site
Industry Sectors
Health & Hospitals


From the reviews:

"This nicely organized and clearly illustrated book provides an up-to-date resource for radiopharmacists and nuclear medicine physicians who compound and prescribe 99mTc-labeled radiopharmaceuticals. Radiochemists and those concerned with regulatory affairs also will be interested, and the book could be used as a primary text in nuclear medicine training programs. This outstanding book fills a void and is the first compilation of its kind in many years. We recommend it with the highest enthusiasm." (Susan Z. Lever and John R. Lever, Journal of Nuclear Medicine, May, 2009)