• Christoph Stein

Part of the Handbook of Experimental Pharmacology book series (HEP, volume 177)

Table of contents

  1. Front Matter
    Pages I-IX
  2. Introduction

    1. Front Matter
      Pages 1-1
  3. Drugs in Clinical Use

    1. Front Matter
      Pages 29-29
    2. C. Zöllner, C. Stein
      Pages 31-63
    3. F. Yanagidate, G. R. Strichartz
      Pages 95-127
    4. A. H. Dickenson, J. Ghandehari
      Pages 145-177
  4. Compounds in Preclinical Development

    1. Front Matter
      Pages 179-179
    2. R. G. Hill, K. R. Oliver
      Pages 181-216
    3. V. Neugebauer
      Pages 217-249
    4. R. D. Sanders, M. Maze
      Pages 251-264
    5. I. J. Lever, A. S. C. Rice
      Pages 265-306
  5. Future Targets in Analgesia Research

    1. Front Matter
      Pages 307-307
    2. J. Sawynok
      Pages 309-328
    3. J. N. Wood
      Pages 329-358
    4. R. -R. Ji, Y. Kawasaki, Z. -Y. Zhuang, Y. -R. Wen, Y. -Q. Zhang
      Pages 359-389
  6. Pain Management Beyond Pharmacotherapy

    1. Front Matter
      Pages 391-391
  7. Back Matter
    Pages 429-435

About this book


Analgesics are among the oldest drugs described, albeit not necessarily for medicinaluse. Forexample,theSumeriansisolatedopioids(probablyfortheir euphoric effects) in the third millennium b. c. and the use of willow bark (salicin) for fever was ?rst reported in the eighteenth century. Both types of drugs are still in use, but today they are supplemented by a wide array of substances ranging from antidepressants to ion channel blockers. Not all of theseareprescribedbyphysicians. Manycompoundsaresoldoverthecounter and thus available to the public for self-medication. As a result, analgesics are also the most misused class of drugs and are the culprit for a multitude of healthproblemsdueto untoward sideeffects. Thisvolumeattemptstosummarizethecurrentstateofknowledgeonme- anisms underlying the various effects of these drugs, their side effect pro?les, and their indications and contraindications in clinical use. It also gives - sights into current efforts to discover novel mechanisms underlying different types of pain generation and the resulting development of new modulating compounds. Theseefforts haveemergedmostlyas aconsequenceofthemore profound insights provided by molecular methods and of the now common use of animal models of pathological, rather than physiological, pain. These important issues are elaborated in the introductory chapter. In parallel, c- temporaryinterdisciplinarytreatmentapproacheshavetaughtusthatsomatic mechanisms alone cannot explain pain; it is an experience shaped as well by social context, memory, and other psychological phenomena. Thus, the book closes with two chapters putting pharmacological strategies into a broader perspective. All of these advancements culminate in the contemporary c- mon goal of developing mechanism-based rather than empiric approaches to thetreatment ofpain.


Arthritis Cancer Cannabinoid Headache Inflammation Opioid Pain Plasticity Signaling

Editors and affiliations

  • Christoph Stein
    • 1
  1. 1.Department of Anesthesiology and Critical Care Medicine Charité — Campus Benjamin FranklinFree University BerlinBerlinGermany

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