© 2006

Chemokines and Viral Infection

  • Thomas E. Lane

Part of the Current Topics in Microbiology and Immunology book series (CT MICROBIOLOGY, volume 303)

About this book


This edition of Current Topics in Microbiology and Immunology examines the role of chemokines and chemokine receptors in host defense and disease development following viral infection. Chemokines represent a family of over 40 small proteins that, for the most part, are secreted into the environment and function by binding to G protein-coupled receptors (GPCRs) that are expressed on numerous different cell types. When initially identified close to 30 years ago, these molecules were associated with various human inflammatory diseases and it was recognized that expression may be integral in leukocyte recruitment to inflamed tissue. There are now four sub-families of chemokines identified based on defined structural criteria relating to the positional location of conserved cysteine residues within the amino-terminus of the protein. Chemokines are now recognized as important in numerous biological processes ranging from maintaining the organizational integrity of secondary lymphoid tissue to participating in various aspects of both innate and adaptive immune responses following microbial infection. With this in mind, this book highlights the functional roles of chemokines and their receptors in participating in various aspects of the immune response against well-known viral pathogens.


Chemokine antiviral defense cell cytokine cytokines diseases immunosuppressive lentivirus infection infection infections lymphocytes pathogenesis protein proteins viral infection virus

Editors and affiliations

  • Thomas E. Lane
    • 1
  1. 1.Department of Molecular Biology and Biochemistry, Center for ImmunologyUniversity of California, IrvineIrvineUSA

Bibliographic information

  • Book Title Chemokines and Viral Infection
  • Editors Thomas E. Lane
  • Series Title Current Topics in Microbiology and Immunology
  • DOI
  • Copyright Information Springer-Verlag Berlin Heidelberg 2006
  • Publisher Name Springer, Berlin, Heidelberg
  • eBook Packages Biomedical and Life Sciences Biomedical and Life Sciences (R0)
  • Hardcover ISBN 978-3-540-29207-4
  • Softcover ISBN 978-3-642-06717-4
  • eBook ISBN 978-3-540-33397-5
  • Series ISSN 0070-217X
  • Edition Number 1
  • Number of Pages XI, 160
  • Number of Illustrations 0 b/w illustrations, 0 illustrations in colour
  • Topics Medical Microbiology
  • Buy this book on publisher's site
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