Escherichia coli, a Versatile Pathogen

  • Gad Frankel
  • Eliora Z Ron

Part of the Current Topics in Microbiology and Immunology book series (CT MICROBIOLOGY, volume 416)

Table of contents

  1. Front Matter
    Pages i-vii
  2. Ilia Belotserkovsky, Philippe J. Sansonetti
    Pages 1-26
  3. Claire Jenkins
    Pages 27-50
  4. Sabrina L. Slater, Agnes M. Sågfors, Dominic J. Pollard, David Ruano-Gallego, Gad Frankel
    Pages 51-72
  5. Avinash R. Shenoy, R. Christopher D. Furniss, Philippa J. Goddard, Abigail Clements
    Pages 73-115
  6. Stefanie Kampmeier, Michael Berger, Alexander Mellmann, Helge Karch, Petya Berger
    Pages 117-148
  7. Dvora Biran, Eliora Z. Ron
    Pages 149-161
  8. Barbara Nesta, Mariagrazia Pizza
    Pages 213-242

About this book


Escherichia coli is a facultative anaerobic Gamma-proteobacterium, which belongs to the family Enterobacteriaceae. While being an important constituent of the normal gut microbiota, specialized E. coli clones have acquired genetic elements that allow them to compete with the endogenous commensals, colonise normally sterile niches and cause disease. E. coli pathotypes can cause intestinal and extra intestinal infections (e.g. UTI, sepsis) and associate with mammalian cells while being extra- or intra-cellular. In recent years, E. coli infections have become a serious clinical problem, due to the rapid spread of antibiotic resistance. Thus, infections with intestinal E. coli (e.g. E. coli O104) or extraintestinal pathogenic strains (e.g. E. coli ST131) are becoming difficult to treat and are often lethal. Consequently, there is a pressing need to develop alternative control measures, including the identification of new drug targets and development of vaccines that offer lasting protection.

This volume focuses on several types of E. coli infections (intestinal and extraintestinal), virulence factors, and E. coli pandemics. It addresses the problem of antibiotic resistance, and a dedicated chapter discusses the need to develop alternative control measures. Given its depth and breadth of coverage, the book will benefit all those interested in the biology, genetics, physiology and pathogenesis of E. coli, and in related vaccine development.


Pathogenic bacteria Type three secretion Escherichia coli enteritis Enteroaggregative Escherichia coli Enteritis

Editors and affiliations

  • Gad Frankel
    • 1
  • Eliora Z Ron
    • 2
  1. 1.Department of Life SciencesImperial College LondonLondonUK
  2. 2.Faculty of Life SciencesTel Aviv UniversityTel AvivIsrael

Bibliographic information

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