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ADME Processes in Pharmaceutical Sciences

Dosage, Design, and Pharmacotherapy Success

  • Alan Talevi
  • Pablo A. M. Quiroga

Table of contents

  1. Front Matter
    Pages i-x
  2. The Basics of ADME Processes

    1. Front Matter
      Pages 1-1
    2. Alan Talevi, Pablo A. M. Quiroga
      Pages 3-10
    3. Alan Talevi, Carolina Leticia Bellera
      Pages 11-31
    4. Alan Talevi, Carolina Leticia Bellera
      Pages 33-53
    5. Alan Talevi, Carolina Leticia Bellera
      Pages 55-80
    6. Alan Talevi, Carolina Leticia Bellera
      Pages 81-96
    7. María Esperanza Ruiz, Sebastián Scioli Montoto
      Pages 97-133
    8. Germán Abel Islan, Sergio Martin-Saldaña, Merari Tumin Chevalier, Vera Alejandra Alvarez, Guillermo Raúl Castro
      Pages 135-165
  3. The Importance of ADME Properties in Burgeoning Pharmaceutical Topics

    1. Front Matter
      Pages 167-167
    2. Venkata K. Yellepeddi, Jessica K. Roberts, Leslie Escobar, Casey Sayre, Catherine M. Sherwin
      Pages 203-222
    3. Z. Gulsen Oner, James E. Polli
      Pages 223-240
    4. Pietro Fagiolino, Marta Vázquez, Manuel Ibarra, Cecilia Maldonado, Rosa Eiraldi
      Pages 271-299
    5. Angela Effinger, Caitriona M. O’Driscoll, Mark McAllister, Nikoletta Fotaki
      Pages 301-330
    6. Alan Talevi, Carolina Leticia Bellera, Guido Pesce
      Pages 331-348
  4. Back Matter
    Pages 349-362

About this book

Introduction

Absorption, Distribution, Metabolism and Excretion (ADME) processes and their relationship with the design of dosage forms and the success of pharmacotherapy form the basis of this upper level undergraduate/graduate textbook. As an introduction oriented to pharmacy students, it is also written for scientist from different fields outside of pharmaceutics. (e.g. material scientist, material engineers, medicinal chemists) who might be working in a positions in pharmaceutical companies or whose work might benefit from basic training in the ADME concepts and some biological background. 

Pedagogical features such as objectives, keywords, discussion questions, summaries and case studies add valuable teaching tools. This book will provide not only general knowledge on ADME processes but also an updated insight on some hot topics such as drug transporters, multi-drug resistance related to pharmacokinetic phenomena, last generation pharmaceutical carriers (nanopharmaceuticals), in vitro and in vivo bioequivalence studies, biopharmaceuticals, pharmacogenomics, drug-drug and food-drug interactions, and in silico and in vitro prediction of ADME properties. In comparison with other similar textbooks, around half of the volume would be focused on the relationship between expanding scientific fields and ADME processes. Each of these burgeoning fields has a separate chapter in the second part of the volume, and was written with leading experts on the correspondent topic, including scientists and academics from USA and UK (Duquesne University School of Pharmacy, Indiana University School of Medicine, University of Utah College of Pharmacy, University of Maryland, University of Bath).

Additionally, each of the initial chapters dealing with the generalities of drug absorption, distribution, metabolism and excretion would include relevant, classic examples related to each topic with appropriate illustrations (e.g. importance of active absorption of levodopa, implications in levodopa administration, drug drug interactions and food drug interactions emerging from the active uptake; intoxication with paracetamol as a result of glutathione depletion, CYP induction and its relationship with acute liver failure caused by paracetamol, etc).

ADME Processes and Pharmaceutical Sciences is written as a core textbook for ADME processes, pharmacy, pharmacokinetics, drug delivery, biopharmaceutics, drug disposition, drug design and medicinal chemistry courses.

Keywords

ADME Pharmacodynamics Pharmacokinetics Absorption, Delivery, Metabolism and Excretion dosage forms pharmacotherapy drug disposition drug transporters mutli-drug resistance nanopharmaceuticals Pharmacogenomics in silico drug testing in virto drug testing

Editors and affiliations

  • Alan Talevi
    • 1
  • Pablo A. M. Quiroga
    • 2
  1. 1.Laboratory of Bioactive Research and Development (LIDeB), Department of Biological Sciences, Faculty of Exact SciencesUniversity of La Plata (UNLP)La PlataArgentina
  2. 2.Quality Control of Pharmaceutical Products, Pharmaceutical Toxicology, Department of Biological Sciences, Faculty of Exact SciencesUniversidad Nacional de La PlataLa PlataArgentina

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