Critical Issues in Head and Neck Oncology

Key Concepts from the Sixth THNO Meeting

  • Jan B. Vermorken
  • Volker Budach
  • C. René Leemans
  • Jean-Pascal Machiels
  • Piero Nicolai
  • Brian O'Sullivan

Table of contents

  1. Front Matter
    Pages i-ix
  2. Epidemiology and Diagnosis

    1. Front Matter
      Pages 1-1
    2. Phil Sloan, Max Robinson
      Pages 15-26
  3. Prediction of Outcome

  4. Oral Cavity Cancer

    1. Front Matter
      Pages 65-65
    2. C. René Leemans, Sat Parmar
      Pages 67-73
    3. Jim Higginson, Prav Praveen, Tim Martin, Sat Parmar
      Pages 75-98
    4. Ing Bing Tan, Sharon D. Stoker, Robert L. P. van Veen
      Pages 105-116
  5. Oropharynx Cancer

    1. Front Matter
      Pages 117-117
    2. Panagiota Economopoulou, Ioannis Kotsantis, Amanda Psyrri
      Pages 119-147
    3. Hisham Mehanna, Jennifer L. Bryant, Anthony H. Kong
      Pages 165-170
    4. Yann Litzistorf, Christian Simon
      Pages 171-180
    5. Volker Budach, Alexander Thieme
      Pages 181-212
  6. Miscellaneous Topics

    1. Front Matter
      Pages 213-213
    2. Nausica Montalto, Francesca Del Bon, Alberto Paderno, Riccardo Morello, Piero Nicolai
      Pages 227-250
    3. Jonathan Pan, Jennifer Johnson, Athanassios Argiris
      Pages 251-265
    4. Salvatore Alfieri, Lisa Licitra
      Pages 277-284
    5. Petr Szturz, Jan B. Vermorken
      Pages 285-307
  7. Thyroid Cancer

    1. Front Matter
      Pages 309-309
    2. John Cramer, Robert L. Ferris
      Pages 319-337
  8. Keynote Address

    1. Front Matter
      Pages 339-339
  9. Back Matter
    Pages 357-363

About this book


This book provides an overview of the latest advances in head and neck cancer using a multidisciplinary approach. Commencing with a discussion of epidemiological and diagnostic aspects, including the role of vaccination and key pathological features, the book then follows by examining the role of oncogenomics, proteomics, next generation sequencing and homologous recombination function in predicting outcomes. The topics are presented by epidemiologists, pathologists and basic scientists with further contributions from medical oncologists, head and neck cancer surgical specialists (ORL /HNS), and radiation oncologists in chapters that discuss therapeutic approaches for oral, oropharyngeal and thyroid cancer. Special topics such as the development of novel staging classifications, optimal larynx preservation approaches for laryngeal and hypopharyngeal cancer, surgical reconstruction, new surgical approaches in oropharynx cancer, potential for treatment de-escalation, systemic therapy in nasopharyngeal cancer and salivary gland tumors and treatment approaches for tumors of unknown primary site are discussed in detail. Finally, the role of immunotherapy in the field is highlighted.

The chapters are based on the latest data presented at the 6th Trends in Head and Neck Oncology Conference and reflect the most up-to-date information in the field. They are written by many of the most internationally acclaimed authors in the field and are therefore an excellent source for all those interested or actively working in the field of head and neck cancer.


cancer epidemiology Oropharyngeal cancer Non-oropharyngeal cancer Rare tumors Thyroid cancer biomarkers Locoregional therapy Systemic therapy Resistance molecular pathology

Editors and affiliations

  • Jan B. Vermorken
    • 1
  • Volker Budach
    • 2
  • C. René Leemans
    • 3
  • Jean-Pascal Machiels
    • 4
  • Piero Nicolai
    • 5
  • Brian O'Sullivan
    • 6
  1. 1.Department of Medical OncologyAntwerp University HospitalEdegemBelgium
  2. 2.Department of Radiation OncologyCharité University MedicineBerlinGermany
  3. 3.Department of Otolaryngology VU University Medical CenterAmsterdamThe Netherlands
  4. 4.Institut Roi Albert IIUniversité Catholique de Louvain Louvain-la-NeuveBelgium
  5. 5.Department of OtorhinolarynologyUniversity of BresciaBresciaItaly
  6. 6.Department of Radiation Oncology, Princess Margaret Cancer CentreUniversity of TorontoTorontoCanada

Bibliographic information

Industry Sectors
Health & Hospitals
Oncology & Hematology