Fibrosis in Disease

An Organ-Based Guide to Disease Pathophysiology and Therapeutic Considerations

  • Monte S. Willis
  • Cecelia C. Yates
  • Jonathan C. Schisler

Part of the Molecular and Translational Medicine book series (MOLEMED)

Table of contents

  1. Front Matter
    Pages i-xix
  2. Skin, Cell Injury, and Wound Healing

    1. Front Matter
      Pages 1-1
    2. Zariel I. Johnson, Christopher Mahoney, Jun Heo, Erin Frankel, Dana R. Julian, Cecelia C. Yates
      Pages 3-24
    3. Yahya Argobi, Gideon P. Smith
      Pages 25-60
    4. Melanie Rodrigues, Clark A. Bonham
      Pages 61-87
  3. Lung

    1. Front Matter
      Pages 89-89
    2. Justin A. Dutta, Harinath Bahudhanapati, Jiangning Tan, Alon Goldblum, Daniel J. Kass
      Pages 91-119
    3. Chiko Shimbori, Chandak Upagupta, Paul Forsythe, Martin Kolb
      Pages 135-173
    4. Alexander Birbrair, Pedro Henrique Dias Moura Prazeres, Daniel Clark Files, Osvaldo Delbono
      Pages 175-195
    5. Vineela Parvathaneni, Snehal K. Shukla, Vivek Gupta
      Pages 197-237
    6. Janette K. Burgess, Kirsten Muizer, Corry-Anke Brandsma, Irene H. Heijink
      Pages 239-270
  4. Heart

    1. Front Matter
      Pages 271-271
    2. Saranya Ravi, Monte S. Willis, Jonathan C. Schisler
      Pages 273-317
    3. Gentian Lluri, Arjun Deb
      Pages 319-334
  5. Vasculature, Kidney, Liver, and Organ Fibrosis/Metastasis

    1. Front Matter
      Pages 367-367
    2. Mengxue Zhang, Bowen Wang, K. Craig Kent, Lian-Wang Guo
      Pages 369-386
    3. Jennifer Y. Chen, Dhruv Thakar, Tammy T. Chang
      Pages 387-417
    4. Yosuke Hirakawa, Tetsuhiro Tanaka, Masaomi Nangaku
      Pages 419-449
    5. Joseph N. Martel, Vincent Q. Nguyen, Andrew W. Eller
      Pages 451-462
  6. Back Matter
    Pages 463-741

About this book


This book serves as a state-of-the-art resource for physicians and translational medical researchers alike who are interested in the rapidly evolving field of fibroproliferative diseases. It provides new insight into the fundamental mechanisms of classic fibrotic pathophysiologic processes like myocardial infarction, idiopathic pulmonary fibrosis, chronic kidney disease, wound healing, and systemic sclerosis. It also highlights the many new areas of therapeutic investigation currently underway. Lastly, it touches upon newly emerging fields and investigates the role of fibrosis in macular degeneration and cancer metastasis.

Chapters are written by established experts in their fields, including clinicians, cardiologists, cardiovascular surgeons, pathologists, general practitioners, and translational biomedical researchers in a wide range of disciplines. However, the material also applies to a broader audience, including medical residents, fellows, and M.D. or Ph.D. post-doctoral research fellows. While comprehensive, this book presents the material in a manner that simplifies the complex pathophysiologic mechanisms that underlie common fibroproliferative diseases while making it appealing to a broad audience.


Chemokines systemic sclerosis Fibrotic Signaling peptidomics hepatic fibrosis Anti-Fibrotic Therapies

Editors and affiliations

  • Monte S. Willis
    • 1
  • Cecelia C. Yates
    • 2
  • Jonathan C. Schisler
    • 3
  1. 1.Department of Pathology and Laboratory Medicine, Krannert Institute of CardiologyIndiana University School of Medicine, Indiana Center for Musculoskeletal HealthIndianapolisUSA
  2. 2.Department of Health Promotion and Development, McGowan Institute for Regenerative MedicineUniversity of Pittsburgh School of NursingPittsburghUSA
  3. 3.Department of Pharmacology and Department of Pathology and Lab MedicineMcAllister Heart Institute, The University of North Carolina at Chapel HillChapel HillUSA

Bibliographic information

  • DOI
  • Copyright Information Springer Nature Switzerland AG 2019
  • Publisher Name Humana Press, Cham
  • eBook Packages Medicine Medicine (R0)
  • Print ISBN 978-3-319-98142-0
  • Online ISBN 978-3-319-98143-7
  • Series Print ISSN 2197-7852
  • Series Online ISSN 2197-7860
  • Buy this book on publisher's site
Industry Sectors
Health & Hospitals