© 2019

Cerebrospinal Fluid Disorders

Lifelong Implications

  • David D. Limbrick Jr.
  • Jeffrey R. Leonard


  • The first resource available that compiles recent laboratory advances with current clinical treatment.

  • Presents the current treatments for hydrocephalus across the lifespan.

  • Written by experts in the field.


Table of contents

  1. Front Matter
    Pages i-xii
  2. Normal and Abnormal CSF Physiology

    1. Front Matter
      Pages 1-1
    2. Esteban M. Rodríguez, Maria Montserrat Guerra, Eduardo Ortega
      Pages 3-30
    3. Thomas Garton, Jennifer M. Strahle
      Pages 31-45
    4. Albert M. Isaacs, David D. Limbrick Jr.
      Pages 47-70
  3. Clinical Disorders of CSF

    1. Front Matter
      Pages 85-85
    2. Charuta Gavankar Furey, Prince Antwi, Kristopher Thomas Kahle
      Pages 87-113
    3. Hannah Tully, Annie Laquerriere, Dan Doherty, William Dobyns
      Pages 115-129
    4. Smruti K. Patel, Shawn M. Vuong, Weihong Yuan, Francesco T. Mangano
      Pages 131-151
    5. Jonathan A. Pindrik, Mark Halverson
      Pages 153-173
    6. Michael C. Dewan, John C. Wellons III, Robert P. Naftel
      Pages 185-198
    7. Jonathan Roth, Shlomi Constantini
      Pages 199-217
    8. Albert M. Isaacs, Mark G. Hamilton, Michael A. Williams
      Pages 219-235
    9. David L. Dornbos III, Luke G. F. Smith, Varun Shah, Nicholas Musgrave, Patrick P. Youssef, Ciarán J. Powers et al.
      Pages 237-247
    10. Jason Milton, Jeffrey R. Leonard
      Pages 249-258
    11. David L. Dornbos III, Nathaniel Toop, Ammar Shaikhouni, H. Wayne Slone, John M. McGregor
      Pages 259-277
  4. Treatment of CSF Disorders

    1. Front Matter
      Pages 279-279
    2. William E. Whitehead
      Pages 281-295

About this book


This book is designed to provide the current state-of-the-field for CSF disorders that occur across the lifespan. The authors of the following chapters are true content experts and provide their accumulated knowledge, experience, and wisdom in addition to a thoughtful view forward. We begin with a discussion of the ventricles themselves, with changes in the ependyma that occurs throughout development and as the brain matures and then ages.  Pathophysiological changes and their role in hydrocephalus of various etiologies are considered.  Alterations in CSF composition, physiology, and flow are also discussed in the context of neurodevelopment and neurodegeneration.


Hydrocephalus MR Elastography Rapid Brain MRI Subarachnoid Hemorrhage ETV-CPC

Editors and affiliations

  • David D. Limbrick Jr.
    • 1
  • Jeffrey R. Leonard
    • 2
  1. 1.Department of Neurological SurgeryWashington University School of Medicine, St. Louis Children’s HospitalSt. LouisUSA
  2. 2.Nationwide Children’s Hospital, Department of NeurosurgeryThe Ohio State University College of MedicineColumbusUSA

About the editors

David D. Limbrick, Jr., MD, PhD
Department of Neurological Surgery
Washington University School of Medicine
St. Louis Children’s Hospital
St. Louis, MO

Jeffrey R. Leonard, MD 
Division of Pediatric Neurosurgery
Nationwide Children's Hospital
Department of Neurosurgery
The Ohio State University College of Medicine
Columbus, OH

Bibliographic information

  • Book Title Cerebrospinal Fluid Disorders
  • Book Subtitle Lifelong Implications
  • Editors David D. Limbrick Jr.
    Jeffrey R. Leonard
  • DOI
  • Copyright Information Springer Nature Switzerland AG 2019
  • Publisher Name Springer, Cham
  • eBook Packages Medicine Medicine (R0)
  • Hardcover ISBN 978-3-319-97927-4
  • eBook ISBN 978-3-319-97928-1
  • Edition Number 1
  • Number of Pages XII, 387
  • Number of Illustrations 38 b/w illustrations, 36 illustrations in colour
  • Topics Neurosurgery
    Primary Care Medicine
  • Buy this book on publisher's site
Industry Sectors
Health & Hospitals
Surgery & Anesthesiology


“Cerebrospinal Fluid Disorders: Lifelong Implications allows an important, in-depth insight and knowledge extraction for physicians as well as researchers interested in specific aspects of hydrocephalus research and treatment along with guidance to future research and its potential impact on the health care system.” (Petra M. Klinge, Neurosurgery, Vol. 85 (3), September, 2019)