© 2018

Biological Mechanisms of Minimal Residual Disease and Systemic Cancer

  • Julio A.  Aguirre-Ghiso
  • Provides unprecedented insight into the biology of MRD dormancy and metastasis initiation in solid cancers

  • Brings together a unique comparative review of technologies used to detect MRD in solid cancers and hematological malignancies

  • Reviews the mechanistic underpinnings and modern monitoring modalities for dormant MRD and recurrence in hematological malignancies


Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 1100)

Table of contents

  1. Front Matter
    Pages i-ix
  2. Maria Jose Carlini, Nitisha Shrivastava, Maria Soledad Sosa
    Pages 1-18
  3. Frank C. Cackowski, Russell S. Taichman
    Pages 47-53
  4. Christoph Sproll, Georg Fluegen, Nikolas H. Stoecklein
    Pages 55-82
  5. Alexandra Gomez-Arteaga, Monica L. Guzman
    Pages 111-125
  6. Back Matter
    Pages 161-162

About this book


This book focuses on the biological mechanisms of minimal residual disease (MRD) and recurrence. It integrates this biology in solid cancers and in hematological malignancies. It reports also on technological advancements for monitoring MRD, derived from mechanistic insights. Chapters in solid and hematological malignancies address stem cell biology, genetics, epigenetics and micro-environmental regulation of dormant MRD. Novel insight into technologies for molecular phenotyping of MRD and monitoring of CTCs, DTCs and cell free RNA and DNA are also addressed extensively.

Five chapters explore the above concepts in solid cancers such as prostate, breast, melanoma, head and neck and esophageal. Two chapters also explore the basic mechanisms of vascular biology targeting and epigenetic mechanisms regulating pluripotency programs during dormancy. Similar biology is explored in hematological malignancies such as T-ALL, CML, AML and multiple myeloma in additional four chapters.

This book is edited and prefaced by Dr. Julio Aguirre-Ghiso, an expert in dormancy and recurrence. The chapters are written by world-recognized experts Drs. Ravi Bahtia, Samir Parekh, Russel Taichman, Monica Guzman, David Hoon, Denis Schewe, Irmela Jeremias, Cyrus Ghajar, Maria Soledad Sosa and Nicholas Stoecklein.

The topic of this book is of particular interest to both basic cancer cell biologists and physician scientists that are working to provide a more integrated view of the biology of MRD and to those interested in working on or learning about this paradigm. The integrated and cross-disciplinary focus of the book from biology to medicine seeks to help bridge gaps to improve cancer care and prevent recurrences.


Metastasis Disseminated tumor cells Dormancy Therapy Resistance MRD antibacterial drug resistance

Editors and affiliations

  • Julio A.  Aguirre-Ghiso
    • 1
  1. 1.Division of Hematology and Oncology, Department of Medicine, Department of Otolaryngology, Department of Oncological Sciences, Tisch Cancer Institute, Black Family Stem Cell Institute, Mount Sinai School of MedicineIcahn School of Medicine at Mount SinaiNew YorkUSA

About the editors

Professor Dr. Julio Aguirre-Ghiso is the Director of Head and Neck Cancer Basis Research and Solid Tumor and Metastasis Research. His research group is part of the Division of Hematology and Oncology, Department of Medicine in Mount Sinai. Professor Aguirre-Ghiso has made outstanding contributions in unraveling the Biology of Residual Disease. 

Bibliographic information

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