© 2018

Cardiac Extracellular Matrix

Fundamental Science to Clinical Applications

  • Eric G. Schmuck
  • Peiman Hematti
  • Amish N. Raval
  • Comprehensively discusses recent discoveries in the field

  • Presents novel experimental approaches to developing potential therapies, including implications for Regenerative Medicine

  • Section on Clinical Applications highlights therapeutic strategies, clinical trial design, current human trials and the role of pharma and biotech companies

  • Essential reading for those in research, clinical practice, or industry


Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 1098)

Table of contents

  1. Front Matter
    Pages i-xii
  2. Michael Nguyen-Truong, Zhijie Wang
    Pages 1-19
  3. Michael A. Pinkert, Rebecca A. Hortensius, Brenda M. Ogle, Kevin W. Eliceiri
    Pages 21-44
  4. Mark C. Daley, Spencer L. Fenn, Lauren D. Black III
    Pages 59-83
  5. Karis R. Tang-Quan, Nicole A. Mehta, Luiz C. Sampaio, Doris A. Taylor
    Pages 85-114
  6. Keith L. Spinali, Eric G. Schmuck
    Pages 115-130
  7. Mikayla L. Hall, Brenda M. Ogle
    Pages 131-150
  8. Jenna L. Dziki, Stephen F. Badylak
    Pages 151-171
  9. Adrian P. Gee
    Pages 189-198
  10. Back Matter
    Pages 237-246

About this book


This book on cardiac extracellular matrix (ECM) features three sections, Fundamental Science, Pre-Clinical and Translational Science, and Clinical Applications. In the Fundamental Science section, we will cover the spectrum of basic ECM science from ECM’s role in development, biomechanical properties, cardiac ECM influence of cardiomyocyte biology, pathophysiology of ECM in heart disease, and ECM in tissue engineering. Section two, Preclinical and Translational Science, will discuss cardiac ECM technologies in the clinical pipeline including approaches to ECM as a therapeutic, animal models of cardiac research, tracking and imaging methods of cardiac ECM, and cGMP manufacturing and regulatory considerations for ECM based therapeutics. Finally, the third section, Clinical Applications, will highlight the clinical experience around cardiac ECM including therapeutic strategies targeting scar tissue in the heart, Clinical trial design and regulatory considerations, current human clinical trials in cardiovascular medicine and the role of pharmaceutical and biotech companies in the commercialization of ECM technologies for cardiovascular indications. This book provides a comprehensive review for basic and translational researchers as well as clinical practitioners and those involved in commercialization, regulatory and entrepreneurial activities.


developmental biology cardiac medicine heart disease cellular therapies cardiac scar tissue

Editors and affiliations

  • Eric G. Schmuck
    • 1
  • Peiman Hematti
    • 2
  • Amish N. Raval
    • 3
  1. 1.School of Medicine & Public HealthUniversity of Wisconsin-MadisonMadisonUSA
  2. 2.School of Medicine & Public HealthUniversity of Wisconsin-MadisonMadisonUSA
  3. 3.School of Medicine & Public HealthUniversity of Wisconsin-MadisonMadisonUSA

About the editors

​Eric Schmuck, PhD, is a Senior Scientist with the Division of Cardiovascular Medicine at the University of Wisconsin-Madison School of Medicine and Public Health where he leads multi-disciplinary research teams focused on bringing regenerative medicine therapies to the clinic. He received his PhD in Human Physiology from the University of Wisconsin-Madison and is an expert in cardiac extracellular matrix and translational research models, specifically focusing on cardiac regeneration. His major research interests are in cardiac extracellular matrix, bioengineering and regenerative medicine therapies for the heart.  He has authored numerous peer-reviewed manuscripts and book chapters in the regenerative medicine field and holds multiple patents on cardiac extracellular matrix technologies. Finally, he is a co-founder and Chief Scientific Officer of Cellular Logistics Inc., a biotech company developing innovative biomaterial solutions to enhance stem cell retention for the treatment of advanced cardiovascular disease.

Peiman Hematti, MD is Professor of Medicine in section of Hematology/Oncology, UW-Madison School of Medicine and Public Health, with joint appointments in departments of pediatrics, surgery and biomedical engineering. He is director of Clinical Hematopoietic Cell Processing Laboratory, and medical director of Apheresis and Hematopoietic Cell Collection facility at University of Wisconsin-Madison. As a bone marrow stem cell transplant physician, his major clinical research interest is in immunology of transplantation and use of novel cellular therapies for malignant and non-malignant disorders, including use of bone marrow stem cells in cardiovascular medicine. His current laboratory research focuses on immunobiology of stem cell transplantation with a special focus on investigating the immunomodulatory and anti-inflammatory properties of macrophages, including their interactions with biomaterials used in regenerative medicine. He has been a co-author in more than 100 peer-reviewed manuscripts, 10 book chapters, and has been co-editor of two other books in the field of stem cells and regenerative medicine.  He has been inventor of several patents issued and filed in the field of cellular therapy and regenerative medicine. He is a co-founder and chair of the Scientific Advisory Board for Cellular Logistics Inc.

Amish N. Raval MD is an Associate Professor of Medicine and Biomedical Engineering at the University of Wisconsin. He received his MD at the U. of Western Ontario, where he completed Internal Medicine and Cardiology Residency.  He subsequently completed his Interventional Cardiology Fellowship at Georgetown University/Washington Hospital Center, and later, he joined the National Heart, Lung and Blood Institute, Bethesda.  Thereafter, he became a Faculty member at the University of Wisconsin School of Medicine and Public Health where he is Di^12 cardiovascular regenerative medicine clinical trials ranging from Phase 1 to 3. He has served as a scientific advisor for several biotech companies and is Chairman of the Board for Cellular Logistics Inc, which is a biotech company that is developing innovative biomaterial solutions to enhance stem cell retention for the treatment of advanced cardiovascular disease.

Bibliographic information

  • Book Title Cardiac Extracellular Matrix
  • Book Subtitle Fundamental Science to Clinical Applications
  • Editors Eric G. Schmuck
    Peiman Hematti
    Amish N. Raval
  • Series Title Advances in Experimental Medicine and Biology
  • Series Abbreviated Title Adv Exp Med Biol
  • DOI
  • Copyright Information Springer Nature Switzerland AG 2018
  • Publisher Name Springer, Cham
  • eBook Packages Biomedical and Life Sciences Biomedical and Life Sciences (R0)
  • Hardcover ISBN 978-3-319-97420-0
  • Softcover ISBN 978-3-030-07353-4
  • eBook ISBN 978-3-319-97421-7
  • Series ISSN 0065-2598
  • Series E-ISSN 2214-8019
  • Edition Number 1
  • Number of Pages XII, 246
  • Number of Illustrations 2 b/w illustrations, 33 illustrations in colour
  • Topics Cell Biology
    Biomedical Engineering/Biotechnology
    Cardiac Surgery
  • Buy this book on publisher's site
Industry Sectors
Health & Hospitals