Table of contents

  1. Front Matter
    Pages i-viii
  2. Jessica P. Anand, Deanna Montgomery
    Pages 21-51
  3. Ana Vicente-Sanchez, Amynah A. Pradhan
    Pages 73-85
  4. Catherine M. Cahill, Edmund Ong
    Pages 115-127
  5. Richard C. Crist, Toni-Kim Clarke
    Pages 131-145
  6. Khaled Abdallah, Louis Gendron
    Pages 147-177
  7. Isaac J. Dripps, Emily M. Jutkiewicz
    Pages 179-197
  8. Doungkamol Alongkronrusmee, Terrance Chiang, Richard M. van Rijn
    Pages 199-225
  9. L. P. Pellissier, C. N. Pujol, J. A. J. Becker, J. Le Merrer
    Pages 227-260
  10. M. Grant Liska, Marci G. Crowley, Trenton Lippert, Sydney Corey, Cesar V. Borlongan
    Pages 277-299
  11. Louise See Hoe, Hemal H. Patel, Jason N. Peart
    Pages 301-334
  12. Mei Bigliardi-Qi, Paul Bigliardi
    Pages 335-345

About this book


This volume describes our current understanding of the biological role of the delta-opioid receptor (DOR) system, focusing on its unique mechanisms of receptor trafficking and signaling in disease states. Part 1 covers the endogenous ligands that regulate the DOR system as well as novel compounds and therapies used to modulate the DOR system. Part 2 describes new insights into the localization and trafficking of the DOR and how ligand-directed signaling alters the fate of the receptor. Part 3 concentrates on the potential role of the DOR system in disease states, such as pain, mood, addiction, and Parkinson’s disease. Throughout the book, the DOR system as a target for drug development will be discussed.


CNS-related diseases Enkephalin biased agonism drug development pain, emotion and addiction receptor trafficking

Editors and affiliations

  • Emily M. Jutkiewicz
    • 1
  1. 1.Department of PharmacologyUniversity of Michigan Medical SchoolAnn ArborUSA

Bibliographic information

  • DOI
  • Copyright Information Springer International Publishing AG, part of Springer Nature 2018
  • Publisher Name Springer, Cham
  • eBook Packages Biomedical and Life Sciences
  • Print ISBN 978-3-319-95131-7
  • Online ISBN 978-3-319-95133-1
  • Series Print ISSN 0171-2004
  • Series Online ISSN 1865-0325
  • Buy this book on publisher's site
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