Particles and Nanoparticles in Pharmaceutical Products

Design, Manufacturing, Behavior and Performance

  • Henk G. Merkus
  • Gabriel M. H. Meesters
  • Wim Oostra

Part of the AAPS Advances in the Pharmaceutical Sciences Series book series (AAPS, volume 29)

Table of contents

  1. Front Matter
    Pages i-xii
  2. Henk G. Merkus
    Pages 1-52
  3. Henk G. Merkus
    Pages 53-83
  4. Martin Kluenker, Sven Kurch, Muhammad Nawaz Tahir, Wolfgang Tremel
    Pages 85-170
  5. Ana Filipa Cruz, Nuno A. Fonseca, Ana C. Gregório, Vera Moura, Sérgio Simões, João Nuno Moreira
    Pages 171-211
  6. Anthony J. Hickey
    Pages 213-232
  7. Carl A. Anderson, Natasha L. Velez
    Pages 233-275
  8. Jon Hilden, Christopher L. Burcham, Stephen D. Stamatis, Jim Miesle, Carrie A. Coutant
    Pages 277-302
  9. Giuseppina Sandri, Maria Cristina Bonferoni, Silvia Rossi, Carla M. Caramella, Franca Ferrari
    Pages 303-328
  10. Sheila Khodadadi, Gabriel M. H. Meesters
    Pages 329-346
  11. Antonietta M. Gatti, Stefano Montanari
    Pages 429-443
  12. Back Matter
    Pages 445-446

About this book


This edited volume brings together the expertise of numerous specialists on the topic of particles – their physical, chemical, pharmacological and toxicological characteristics – when they are a component of pharmaceutical products and formulations. The book discusses in detail properties such as the composition, size, shape, surface properties and porosity of particles with respect to how they impact the formulations and products in which they are used and the effective delivery of pharmaceutical active ingredients. It considers all dosage forms of pharmaceuticals involving particles, from powders to tablets, creams to ointments, and solutions to dry-powder inhalers, also including the latest nanomedicine products. Further, it discusses examples of particle toxicity, as well as the important subject of pharmaceutical industry regulations, guidelines and legislation.
The book is of interest to researchers and practitioners who work on testing and developing pharmaceutical dosage and delivery systems.


Pharmaceutical particulate Pharmaceutical emulsions and suspensions Particle surface properties Pharmaceutical particles legislation Controlled-release particles

Editors and affiliations

  • Henk G. Merkus
    • 1
  • Gabriel M. H. Meesters
    • 2
  • Wim Oostra
    • 3
  1. 1.PijnackerThe Netherlands
  2. 2.DelftThe Netherlands
  3. 3.HilversumThe Netherlands

Bibliographic information

Industry Sectors
Materials & Steel
Chemical Manufacturing
Consumer Packaged Goods
Energy, Utilities & Environment
Oil, Gas & Geosciences