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Immunotherapy of Sarcoma

  • Sandra P. D'Angelo
  • Seth M. Pollack

Table of contents

  1. Front Matter
    Pages i-vii
  2. The Sarcoma Immune Microenvironment

    1. Front Matter
      Pages 1-1
    2. Brittany Lala, Anusha Kalbasi, Arun S. Singh
      Pages 3-15
    3. Gerardo A. Vitiello, Benjamin D. Medina, Ronald P. DeMatteo
      Pages 17-31
    4. Vaia Florou, Breelyn A. Wilky
      Pages 33-45
    5. Amy J. Wisdom, Yvonne M. Mowery, David G. Kirsch
      Pages 47-65
  3. Sarcoma Immunotherapeutics

    1. Front Matter
      Pages 67-67
    2. Varun Monga, Seth M. Maliske, Mohammed Milhem
      Pages 69-116
    3. Swathi Namburi, Melissa Burgess
      Pages 117-123
    4. Sandra P. D’Angelo, Ciara M. Kelly
      Pages 125-137
    5. Seth M. Pollack, Georgios Antoniou
      Pages 139-152

About this book

Introduction

This book describes recent progress in the development of immunotherapies for advanced sarcoma, paying special attention to the potential role of manipulations of the sarcoma tumor immune microenvironment in achieving durable remissions. Readers will find a thorough overview of the state of the art in tumor immunology and immunotherapy as they relate to sarcoma. Among the topics addressed are advances in vaccine therapy; the value of adoptive transfer of cytokine-induced natural killer cells; the development of adoptive T cell strategies; and the scope for use of checkpoint inhibitors in patients with sarcoma, mirroring the tremendous breakthroughs made in other malignancies. Detailed information is provided on laboratory and clinical research, with analysis of outcomes of recent trials and identification of key challenges. There is every reason to believe that more effective and less toxic therapies for metastatic sarcoma can be attained by deepening our understanding of cancer immunology and building on the advances in immunotherapy for other solid tumors. In this context, Immunotherapy of Sarcoma will be of high interest for all medical oncologists responsible for the treatment of sarcoma patients.

Keywords

Soft Tissue Sarcoma Bone Sarcoma Immunotherapy Check-point Inhibitors Adoptive T Cell Therapy Tumor Immune Microenvironment

Editors and affiliations

  • Sandra P. D'Angelo
    • 1
  • Seth M. Pollack
    • 2
  1. 1.Department of Sarcoma Medical OncologyMemorial Sloan Kettering Cancer Center and Weill Cornell Medical CollegeNew YorkUSA
  2. 2.Fred Hutchinson Cancer Research CenterUniversity of WashingtonSeattleUSA

Bibliographic information

  • DOI https://doi.org/10.1007/978-3-319-93530-0
  • Copyright Information Springer International Publishing AG, part of Springer Nature 2019
  • Publisher Name Springer, Cham
  • eBook Packages Medicine
  • Print ISBN 978-3-319-93529-4
  • Online ISBN 978-3-319-93530-0
  • Buy this book on publisher's site
Industry Sectors
Pharma
Health & Hospitals
Biotechnology