Systems Biology

  • Nikolaus Rajewsky
  • Stefan Jurga
  • Jan Barciszewski

Part of the RNA Technologies book series (RNATECHN)

Table of contents

  1. Front Matter
    Pages i-x
  2. Zahra Fahmi, Sven A. Sewitz, Karen Lipkow
    Pages 1-15
  3. Khushdeep Bandesh, Pawan K. Dhar, Dwaipayan Bharadwaj
    Pages 17-36
  4. Julia Wong, Ignatius Pang, Marc Wilkins, Jai J. Tree
    Pages 97-127
  5. Ali Nehme, Zahraa Awada, Firas Kobeissy, Frédéric Mazurier, Kazem Zibara
    Pages 153-172
  6. Francesco Russo, Federico De Masi, Søren Brunak, Kirstine Belling
    Pages 229-238
  7. Andrea Riba, Matteo Osella, Michele Caselle, Mihaela Zavolan
    Pages 257-273
  8. Yoram Zarai, Michael Margaliot, Tamir Tuller
    Pages 275-300
  9. Kumar Selvarajoo, Vincent Piras, Alessandro Giuliani
    Pages 313-336
  10. Kristian Jensen, Steinn Gudmundsson, Markus J. Herrgård
    Pages 337-350
  11. Anastasia Meshcheryakova, Philip Zimmermann, Rupert Ecker, Felicitas Mungenast, Georg Heinze, Diana Mechtcheriakova
    Pages 351-372
  12. Elena Bencurova, Meik Kunz, Thomas Dandekar
    Pages 373-401

About this book


Many breakthroughs in experimental devices, advanced software, as well as analytical methods for systems biology development have helped shape the way we study DNA, RNA and proteins, on the genomic, transcriptional, translational and posttranslational level. This book highlights the comprehensive topics that encompass systems biology with enormous progress in the development of genome sequencing, proteomic and metabolomic methods in designing and understanding biological systems.

Topics covered in this book include fundamentals of modelling networks, circuits and pathways, spatial and multi cellular systems, image-driven systems biology, evolution, noise and decision-making in single cells, systems biology of disease and immunology, and personalized medicine. Special attention is paid to epigenomics, in particular environmental conditions that impact genetic background. The breadth of exciting new data towards discovering fundamental principles and direct application of epigenetics in agriculture is also described.

The chapter “Deciphering the Universe of RNA Structures and Trans RNA-RNA Interactions of Transcriptomes in vivo - from Experimental Protocols to Computational Analyses” is available open access under a CC BY 4.0 license via


regulatory networks computational methods genome sequencing proteomics metabolomics image-driven systems biology personalized medicine cellular networks modelling networks

Editors and affiliations

  • Nikolaus Rajewsky
    • 1
  • Stefan Jurga
    • 2
  • Jan Barciszewski
    • 3
  1. 1.Max Delbrück Center for Molecular MedicineBerlin Institute for Medical Systems BiologyBerlin-BuchGermany
  2. 2.Nanobiomedical CenterAdam Mickiewicz UniversityPoznańPoland
  3. 3.Polish Academy of SciencesInstitute of Bioorganic ChemistryPoznańPoland

Bibliographic information

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