© 2018

Inflammatory Mechanisms in Mediating Hearing Loss

  • Vickram Ramkumar
  • Leonard P. Rybak

Table of contents

  1. Front Matter
    Pages i-x
  2. Leonard P. Rybak
    Pages 1-13
  3. Samson Jamesdaniel
    Pages 15-30
  4. Elizabeth M. Keithley
    Pages 91-114
  5. Arwa Kurabi, Daniel Schaerer, Allen F. Ryan
    Pages 115-132
  6. Sandeep Sheth, Debashree Mukherjea, Leonard P. Rybak, Vickram Ramkumar
    Pages 149-164
  7. Stefania Goncalves, Enrique Perez, Esperanza Bas, Christine T. Dinh, Thomas R. Van De Water
    Pages 165-187
  8. Alanna M. Windsor, Michael J. Ruckenstein
    Pages 189-210
  9. Back Matter
    Pages 225-231

About this book


The primary goal of this project is to describe our current understanding of the oxidant hypothesis of noise and drug-induced hearing loss and show how this process translates into cochlear inflammation.  Basic cellular mechanisms underlying the contribution of oxidant stress to hearing loss will be explained and molecular pathways leading to inflammatory processes will be outlined. Several different aspects of the cochlear inflammatory process will be discussed in detail. These include the sources of inflammatory cells, chemokines, inflammatory cytokines and the roles of cochlear resident immune cells in mediating hearing loss.  In addition, evidence for a robust cochlear-based steroid axis which is activated by cochlear stress and serves a protective system.  The role of the strial vasculature networks which aid in maintenance of the blood-labyrinth barrier and control the entry of circulating immune cells into the cochlea will be described.  Molecular pathways leading to activation of the local inflammatory process will be highlighted and otoprotective treatment options will be discussed. The relevance of certain clinically used anti-inflammatory interventions, such as trans-tympanic steroids and other drugs will also be discussed. Furthermore, we will examine recent patents focusing on the use of anti-inflammatory agents for the treatment of drug and noise-induced hearing loss.

It is our hope that this book would provide a better understanding of the interaction of oxidative stress and inflammation in hearing loss. This book should provide basic information to scientists in the field of auditory research and to enlighten clinicians who treat patients with potentially ototoxic drugs.


cochlear function oxidative stress lipid mediators therapy anti-inflammatory drugs

Editors and affiliations

  • Vickram Ramkumar
    • 1
  • Leonard P. Rybak
    • 2
  1. 1.Department of Pharmacology, School of MedicineSouthern Illinois UniversitySpringfieldUSA
  2. 2.Division of Otolaryngology, Department of Surgery, School of MedicineSouthern Illinois UniversitySpringfieldUSA

About the editors

Vickram Ramkumar, Ph.D., joined the faculty at Southern Illinois University School of Medicine in 1992.  He is a professor of pharmacology.

Previously he was a research associate in cardiology at Duke University Medical Center in Durham, N.C. (1986-92).

Ramkumar is the author of more than 65 articles.  His research interest is the molecular pharmacology of adenosine receptors in cardiovascular and auditory systems and cellular signal transduction processes.

Dr. Leonard P. Rybak, is a professor and ear, nose and throat specialist whose general otolaryngology practice focuses on sinus disease and obstructive sleep apnea.

Dr. Rybak's professional affiliations include the American College of Surgeons, and the American Academy of Otolaryngology -- Head and Neck Surgery. Locally, he is a member of the Sangamon County Medical Society and of various committees at St. John’s Hospital and the SIU School of Medicine. He serves as president of the Sangamon County Chapter of the Society for Neuroscience.

Bibliographic information

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