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Small Molecules in Oncology

  • Uwe M. Martens

Part of the Recent Results in Cancer Research book series (RECENTCANCER, volume 211)

Table of contents

  1. Front Matter
    Pages i-viii
  2. Martin Steins, Michael Thomas, Michael Geißler
    Pages 1-17
  3. Minna Voigtlaender, Tanja Schneider-Merck, Martin Trepel
    Pages 19-44
  4. Thomas J. Ettrich, Thomas Seufferlein
    Pages 45-56
  5. David F. Heigener, Martin Reck
    Pages 57-65
  6. Claus Garbe, Thomas K. Eigentler
    Pages 77-89
  7. Robert Zeiser, Hana Andrlová, Frank Meiss
    Pages 91-100
  8. Jens Hasskarl
    Pages 101-123
  9. Frank Meiss, Hana Andrlová, Robert Zeiser
    Pages 125-139
  10. Stephanie Berger, Uwe M. Martens, Sylvia Bochum
    Pages 141-151
  11. Marcus Schmidt, Martin Sebastian
    Pages 153-175
  12. Hana Andrlová, Robert Zeiser, Frank Meiss
    Pages 177-186
  13. Helga Wecker, Cornelius F. Waller
    Pages 199-215
  14. Sylvia Bochum, Stephanie Berger, Uwe M. Martens
    Pages 217-233
  15. Justyna Rawluk, Cornelius F. Waller
    Pages 235-246
  16. M. Herden, Cornelius F. Waller
    Pages 247-256
  17. Umberto Malapelle, Biagio Ricciuti, Sara Baglivo, Francesco Pepe, Pasquale Pisapia, Paola Anastasi et al.
    Pages 257-276

About this book

Introduction

This book, written by respected experts, discusses in detail the latest developments in targeted oncology therapy using small molecules. It covers a wide range of small molecules, including tyrosine kinase inhibitors, mTOR, MEK, PARP, and multikinase inhibitors, as well as cell cycle and NTRK interacting agents. For each molecule, aspects such as the chemical structure, mechanism of action, drug targets, drug interactions, preclinical studies, clinical trials, treatment applications, and toxicity are discussed. 

Extensive research into the molecular mechanisms of cancer has heralded a new age of targeted therapy. The field of personalized cancer therapy is now growing rapidly, and the advances being made will mean significant changes in the treatment algorithms for cancer patients. Numerous novel targets that are crucial for the survival of cancer cells can be attacked by small molecules such as protein tyrosine kinase inhibitors. This book is the third edition of Small Molecules in Oncology, but has now been divided into two volumes, with the other volume focusing specifically on small molecules in hematology. 

Keywords

Small Molecules Molecular Mechanisms of Cancer Targeted Therapy Personalized Cancer Therapy Protein Tyrosine Kinease Inhibitors mTOR Proteasome Chemical Structure Drug Interactions Treatment Applications

Editors and affiliations

  • Uwe M. Martens
    • 1
  1. 1.MOLIT InstituteCancer Center Heilbronn-Franken, SLK-ClinicsHeilbronnGermany

Bibliographic information

  • DOI https://doi.org/10.1007/978-3-319-91442-8
  • Copyright Information Springer International Publishing AG, part of Springer Nature 2018
  • Publisher Name Springer, Cham
  • eBook Packages Medicine
  • Print ISBN 978-3-319-91441-1
  • Online ISBN 978-3-319-91442-8
  • Series Print ISSN 0080-0015
  • Series Online ISSN 2197-6767
  • Buy this book on publisher's site
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